Ronald L. Magolda

Medicine · Health Sciences

38h-index8.9kcitations109works0.02yr avg
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Research Topics

Inflammatory mediators and NSAID effects(12), Protease and Inhibitor Mechanisms(11), Cytokine Signaling Pathways and Interactions(11), Chemical Synthesis and Analysis(10), Peptidase Inhibition and Analysis(8)

Publications109 total

(coronary arteries/thromboxane synthetase/platelet aggregation/s
2016
CCDC 750454: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
Recent Advances in Structure-Based Design of Nuclear Hormone Receptors
BENTHAM SCIENCE PUBLISHERS eBooks·2010
The Synthesis and Biological Evaluation of Quinolyl-piperazinyl Piperidines as Potent Serotonin 5-HT<sub>1A</sub>Antagonists
Journal of Medicinal Chemistry·2010· 15 citedOpen Access
Pyridinyl aminohydantoins as small molecule BACE1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 34 citedOpen Access
CCDC 767715: Experimental Crystal Structure Determination
The Cambridge Structural Database·2010Open Access
Design and Synthesis of 5,5′-Disubstituted Aminohydantoins as Potent and Selective Human β-Secretase (BACE1) Inhibitors
Journal of Medicinal Chemistry·2009· 133 citedOpen Access
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: Part II
Bioorganic & Medicinal Chemistry·2009· 25 citedOpen Access
(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A Wingless β-Catenin Agonist That Increases Bone Formation Rate
Journal of Medicinal Chemistry·2009· 52 citedOpen Access
Selective Kv1.5 Blockers: Development of (<i>R</i>)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a Potential Treatment for Atrial Arrhythmia
Journal of Medicinal Chemistry·2009· 25 citedOpen Access
Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer’s Disease
Journal of Pharmacology and Experimental Therapeutics·2009· 157 cited
Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT<sub>1A</sub>receptor antagonist and potential novel antidepressant
British Journal of Pharmacology·2009· 9 citedOpen Access
Discovery of 6-({4-[2-(4-<i>tert</i>-Butylphenyl)-1<i>H</i>-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): An Orally Active Antagonist of the Gonadotropin Releasing Hormone Receptor (GnRH-R)
Journal of Medicinal Chemistry·2009· 15 citedOpen Access
Corrigendum to “Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)” [Bioorg. Med. Chem. Lett. 18 (2008) 5545–5549]
Bioorganic & Medicinal Chemistry Letters·2009· 3 cited
Prodrugs of Perzinfotel with Improved Oral Bioavailability
Journal of Medicinal Chemistry·2009· 29 cited
Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides
Journal of Medicinal Chemistry·2008· 55 citedOpen Access
Indazole-Based Liver X Receptor (LXR) Modulators with Maintained Atherosclerotic Lesion Reduction Activity but Diminished Stimulation of Hepatic Triglyceride Synthesis
Journal of Medicinal Chemistry·2008· 74 citedOpen Access
Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)
Bioorganic & Medicinal Chemistry Letters·2008· 32 citedOpen Access
Itk kinase inhibitors: Initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead
Bioorganic & Medicinal Chemistry Letters·2008· 26 citedOpen Access
P2‐337: Characterization of the affinity of GSI‐953 for binding to gamma‐secretase and comparison to benchmark gamma‐secretase inhibitors
Alzheimer s & Dementia·2008· 3 cited
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Frequent Co-authors

James M. Trzăskos(16), Carl P. Decicco(12), Maryanne Covington(10), Robert Newton(9), Margaret Favata(8), Robert A. Copeland(8), Rui‐Qin Liu(8), K. C. Nicolaou(8), Ruth R. Wexler(7), Peggy Scherle(6), Elizabeth C. Arner(6), W. E. Barnette(6), Bruce Jaffee(5), Menelas N. Pangalos(5), James J.‐W. Duan(5), Zelda R. Wasserman(5), Mingxin Qian(5), David D. Christ(5), Chu‐Biao Xue(5), Andrea J. Daulerio(4)