William Wickner

Dartmouth College — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

93h-index25.6kcitations252works2.02yr avg
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Research Topics

Cellular transport and secretion(122), Bacterial Genetics and Biotechnology(81), Endoplasmic Reticulum Stress and Disease(75), Lipid Membrane Structure and Behavior(68), RNA and protein synthesis mechanisms(66)

Publications252 total

Functional assembly of the Qc-SNARE with Sec18 and Sec17 on membranes
Molecular Biology of the Cell·2025Open Access
Functional Assembly of the Qc-SNARE with Sec18 and Sec17 on Membranes
2025Open Access
SNARE disassembly requires Sec18/NSF side loading
Nature Structural & Molecular Biology·2025· 3 citedOpen Access
Sec18 ATP hydrolysis selectively releases Sec17 from <i>trans</i>-SNARE complexes, inhibiting membrane fusion
Molecular Biology of the Cell·2025· 2 cited
BPS2025 - Sec18 side-loading is essential for universal SNARE recycling across cellular contexts
Biophysical Journal·2025
BPS2025 - Sec18 side-loading is essential for universal SNARE recycling across cellular contexts
Biophysical Journal·2025
Membrane fusion reactions limited by defective SNARE zippering or stiff lipid fatty acyl composition have distinct requirements for Sec17, Sec18, and adenine nucleotide
2024Open Access
After their membrane assembly, Sec18 (NSF) and Sec17 (SNAP) promote membrane fusion
Molecular Biology of the Cell·2024· 6 citedOpen Access
SNARE disassembly requires Sec18/NSF side-loading
2024· 2 citedOpen Access
Sec18 binds the tethering/SM complex HOPS to engage the Qc-SNARE for membrane fusion
Molecular Biology of the Cell·2024· 7 citedOpen Access
MARCKS Effector Domain, a reversible lipid ligand, illuminates late stages of membrane fusion
Molecular Biology of the Cell·2023· 4 citedOpen Access
Efficient fusion requires a membrane anchor on the vacuolar Qa-SNARE
Molecular Biology of the Cell·2023· 9 citedOpen Access
PI3P regulates multiple stages of membrane fusion
Molecular Biology of the Cell·2023· 7 citedOpen Access
Sec18 supports membrane fusion by promoting Sec17 membrane association
Molecular Biology of the Cell·2022· 14 citedOpen Access
Fusion with wild-type SNARE domains is controlled by juxtamembrane domains, transmembrane anchors, and Sec17
Molecular Biology of the Cell·2022· 14 citedOpen Access
Fusion of tethered membranes can be driven by Sec18/NSF and Sec17/αSNAP without HOPS
eLife·2021· 4 citedOpen Access
Author response: Fusion of tethered membranes can be driven by Sec18/NSF and Sec17/αSNAP without HOPS
2021Open Access
Phosphatidylinositol and phosphatidylinositol-3-phosphate activate HOPS to catalyze SNARE assembly, allowing small headgroup lipids to support the terminal steps of membrane fusion
Molecular Biology of the Cell·2021· 16 citedOpen Access
Membrane Fusion can be Driven by Sec18/NSF, Sec17/αSNAP, and <i>trans</i> -SNARE complex without HOPS
2021Open Access
Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering
eLife·2021· 37 citedOpen Access
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Frequent Co-authors

Albert Haas(6), Roland Lill(6), Christian Ungermann(5), Nathan Margolis(4), Randy Schekman(4), Elliott Crooke(4), F. Ulrich Hartl(3), Stewart H. Lecker(3), Santanu Mondal(3), Arnold J. M. Driessen(3), Gary Eitzen(3), Paul Wolfe(3), Andreas Mayer(2), Joseph P. Hendrick(2), Anastassios Economou(2), Lorna Brundage(2), Darren F. Seals(2), Albert Price(2), Benjamin J. Nichols(2), Hugh R.B. Pelham(2)