F. Ulrich Hartl

Max Planck Institute of Biochemistry — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

133h-index68.3kcitations481works10.32yr avg
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Research Topics

Heat shock proteins research(193), Protein Structure and Dynamics(126), Enzyme Structure and Function(122), RNA and protein synthesis mechanisms(66), Endoplasmic Reticulum Stress and Disease(62)

Publications481 total

Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation
2025· 1 citedOpen Access
α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
Molecular Cell·2025· 3 citedOpen Access
Structural analyses define the molecular basis of clusterin chaperone function
Nature Structural & Molecular Biology·2025· 2 citedOpen Access
α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
2025· 2 citedOpen Access
Stiftung zur Förderung des wissenschaftlichen Nachwuchses
BIOspektrum·2024Open Access
Hydrophobic tails enable diverse functions of the extracellular chaperone clusterin
2024Open Access
Regulated Proteolysis Induces Aberrant Phase Transition of Biomolecular Condensates into Aggregates: A Protective Role for the Chaperone Clusterin
Journal of Molecular Biology·2024· 3 citedOpen Access
Single-molecule digital sizing of proteins in solution
Nature Communications·2024· 7 citedOpen Access
Visualizing chaperonin function in situ by cryo-electron tomography
Nature·2024· 22 citedOpen Access
Protein folding: From physico-chemical rules and cellular machineries of protein quality control to AI solutions
Proceedings of the National Academy of Sciences·2024· 5 citedOpen Access
Quantification of endolysosomal leak of alpha-synuclein fibrils by fluorescence complementation v1
2024Open Access
Resolving chaperone-assisted protein folding on the ribosome at the peptide level
Nature Structural & Molecular Biology·2024· 31 citedOpen Access
Mild Immunoprecipitation with Low Background v1
2024Open Access
In vitro coimmunoprecipitation between CHMP2B and alpha-synuclein v1
2024Open Access
Interplay of Proteostasis Capacity and Protein Aggregation: Implications for Cellular Function and Disease
Journal of Molecular Biology·2024· 48 citedOpen Access
Autophagy preferentially degrades non-fibrillar polyQ aggregates
Molecular Cell·2024· 40 citedOpen Access
NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
Nature Communications·2023· 33 citedOpen Access
Calmodulin regulates protease versus co-chaperone activity of a metacaspase
Cell Reports·2023· 8 citedOpen Access
Autophagy preferentially degrades non-fibrillar polyQ aggregates
2023· 3 citedOpen Access
Single-molecule digital sizing of proteins in solution
2023· 1 citedOpen Access
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Frequent Co-authors

Manajit Hayer‐Hartl(13), Thomas Langer(6), Mark S. Hipp(5), Jörg Martin(4), Andreas Bracher(3), Christine Schneider(3), Ismail Moarefi(3), Jason C. Young(3), Arthur L. Horwich(3), Walter Neupert(3), Dmitrij Frishman(3), Matthias Mann(3), Elmar Nimmesgern(3), William Wickner(3), Joseph P. Hendrick(2), Prasad Kasturi(2), Alicia A. Russo(2), Neal Rosen(2), Nikola P. Pavletich(2), Clemens Scheufler(2)