Nikola P. Pavletich

Memorial Sloan Kettering Cancer Center — United States

Medicine · Health Sciences

70h-index39.5kcitations102works0.02yr avg
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Research Topics

Cancer-related Molecular Pathways(41), DNA Repair Mechanisms(26), Ubiquitin and proteasome pathways(17), Microtubule and mitosis dynamics(13), RNA modifications and cancer(13)

Publications102 total

Author response: Structure of the human ATM kinase and mechanism of Nbs1 binding
2022Open Access
Structure of the human ATM kinase and mechanism of Nbs1 binding
2021Open Access
Insights into homology search from cryo-EM structures of RecA-DNA recombination intermediates
Current Opinion in Genetics & Development·2021· 17 citedOpen Access
Structure of the FA core ubiquitin ligase closing the ID clamp on DNA
Nature Structural & Molecular Biology·2021· 45 citedOpen Access
Mechanism of strand exchange from RecA–DNA synaptic and D-loop structures
Nature·2020· 83 citedOpen Access
DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex
Nature·2020· 90 citedOpen Access
Structure of the Fanconi Anemia Core–UBE2T complex poised to ubiquitinate bound FANCI–FANCD2
2019· 9 citedOpen Access
DNA clamp function of the mono-ubiquitinated Fanconi Anemia FANCI-FANCD2 complex
2019· 7 cited
A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization
Cell Reports·2019· 56 citedOpen Access
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
Nature·2017· 518 citedOpen Access
Abstract 4975: A small molecule pan Id protein antagonist shows strong antitumor activity
Cancer Research·2017
Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
2017· 1 cited
N-Terminal Amino Acid Sequence Determination of Proteins byN-Terminal Dimethyl Labeling: Pitfalls and Advantages When Compared with EdmanDegradation Sequence Analysis
Journal of Biomolecular Techniques JBT·2016· 13 citedOpen Access
Dna2 nuclease-helicase structure, mechanism and regulation by Rpa
eLife·2015· 132 citedOpen Access
Author response: Dna2 nuclease-helicase structure, mechanism and regulation by Rpa
2015· 1 citedOpen Access
Correction to <i>N</i>-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. <i>N</i>-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent
Journal of Medicinal Chemistry·2015· 3 cited
Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1
Science·2014· 69 citedOpen Access
mTOR kinase structure, mechanism and regulation
Nature·2013· 1.0k citedOpen Access
Structure and conformational change of a replication protein A heterotrimer bound to ssDNA
Genes & Development·2012· 238 citedOpen Access
Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway
Science·2011· 164 citedOpen Access
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Frequent Co-authors

Philip D. Jeffrey(15), Haijuan Yang(8), Alicia A. Russo(7), Ning Zheng(6), Brenda A. Schulman(6), J. Wade Harper(5), Joan Massagué(5), Svetlana S. Gorina(4), Carl O. Pabo(4), Michael S. Finnin(4), Michele Pagano(4), Yigong Shi(4), William G. Kaelin(3), Julie J. Miller(3), Jie‐Oh Lee(3), E. Kinnucan(3), Paul Kussie(2), Jill R. Donigian(2), Mircea Ivan(2), Ping Wang(2)