J. Wade Harper

St. Jude Children's Research Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

140h-index99.0kcitations458works7.82yr avg
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Research Topics

Ubiquitin and proteasome pathways(156), Cancer-related Molecular Pathways(88), Autophagy in Disease and Therapy(75), Microtubule and mitosis dynamics(52), Epigenetics and DNA Methylation(44)

Publications456 total

Abstract LT001: Exploiting the dependency on DDX19A to induce transcriptional catastrophe in Ewing sarcoma
Cancer Research·2026
Proteome Landscapes Decode Organelle Vulnerabilities in cortical and dopaminergic-like induced neurons Across Lysosomal Storage Disorders
2025· 1 citedOpen Access
Mapping the functional importance of site-specific ubiquitination across the human proteome
2025Open Access
Publisher Correction: Multimodal cell maps as a foundation for structural and functional genomics
Nature·2025Open Access
α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
Molecular Cell·2025· 3 citedOpen Access
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation
Cell·2025· 16 citedOpen Access
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation
Nature Structural & Molecular Biology·2025· 8 citedOpen Access
EndoMAP.v1 charts the structural landscape of human early endosome complexes
Nature·2025· 6 citedOpen Access
p97/VCP is required for piecemeal autophagy of aggresomes
Nature Communications·2025· 8 citedOpen Access
Author Correction: Combinatorial selective ER-phagy remodels the ER during neurogenesis
Nature Cell Biology·2025Open Access
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution
Science Advances·2025· 3 citedOpen Access
Multimodal cell maps as a foundation for structural and functional genomics
Nature·2025· 21 citedOpen Access
The network response to Egf is tissue-specific
iScience·2025Open Access
EndoMAP.v1, a Structural Protein Complex Landscape of Human Endosomes
2025· 1 citedOpen Access
Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST
Science Advances·2025· 3 citedOpen Access
α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
2025· 2 citedOpen Access
Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways
Proceedings of the National Academy of Sciences·2024· 6 citedOpen Access
Endo-IP and lyso-IP toolkit for endolysosomal profiling of human-induced neurons
Proceedings of the National Academy of Sciences·2024· 10 citedOpen Access
Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases
Nature Communications·2024· 10 citedOpen Access
IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion
Cell·2024· 38 cited
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Frequent Co-authors

Stephen J. Elledge(17), Steven P. Gygi(11), Mathew E. Sowa(8), Brenda A. Schulman(6), Edward L. Huttlin(5), João A. Paulo(5), Alban Ordureau(5), Ramin Rad(4), Melanie P. Gygi(4), Laura Pontano Vaites(4), Nikola P. Pavletich(4), Eric J. Bennett(3), Raphael J. Bruckner(3), Kurt Baltier(3), Fana Gebreab(3), John Szpyt(3), Stanley Tam(3), Gabriela Zárraga-Granados(3), Philip D. Jeffrey(3), Deanna M. Koepp(3)