João A. Paulo

Harvard University — United States

Chemistry · Physical Sciences

75h-index24.7kcitations586works5.32yr avg
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Research Topics

Advanced Proteomics Techniques and Applications(93), Ubiquitin and proteasome pathways(60), Mass Spectrometry Techniques and Applications(50), Cellular transport and secretion(47), Endoplasmic Reticulum Stress and Disease(45)

Publications586 total

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform
Science·2026· 3 citedOpen Access
miRISC inhibition causes mitotic defects and synergizes with genotoxic agents in cancers
2025Open Access
Pre-clinical validation of a novel AAV-mediated gene therapy for <i>KCNV2</i> retinopathy improves visual function in a mouse model and expression in patient organoids
2025
An RNA splicing system that excises DNA transposons from animal mRNAs
Nature·2025· 2 citedOpen Access
Harmine Selectively Drives Human Beta Cell Differentiation and Function Via Protein Kinase A Pathways
2025Open Access
&lt;b&gt;Altered molecular regulation of TUG is a central feature of insulin resistant human adipose tissue&lt;/b&gt;
2025Open Access
Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue
Diabetes·2025Open Access
&lt;b&gt;Altered molecular regulation of TUG is a central feature of insulin resistant human adipose tissue&lt;/b&gt;
2025Open Access
Evaluating the Robustness of Micro-Pillar Array Columns for Quantitative Proteomics Applications
Journal of Proteome Research·2025
A triple-action PROTAC for wild-type p53 cancer therapy
Cell Reports Medicine·2025Open Access
Endocrine-disrupting chemical exposure during differentiation alters the proliferation–maturation balance in stem-cell islets
Toxicological Sciences·2025Open Access
Decoding spliceosome inhibition: Isobaric tag-based proteomic profiling of pladienolide B treated human cell lines
Journal of Proteomics·2025Open Access
Abstract 4365681: Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α
Circulation·2025
Caloric Restriction Substantially Improves Glucose Regulation in Mice With Hnf1a‐Deficient Beta‐Cells
Acta Physiologica·2025· 2 cited
Retinal proteomics in neurodegeneration: Insights into ocular and brain disorders
Neural Regeneration Research·2025Open Access
Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas
Nature Genetics·2025· 1 cited
Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas
2025Open Access
Proteome Landscapes Decode Organelle Vulnerabilities in cortical and dopaminergic-like induced neurons Across Lysosomal Storage Disorders
2025· 1 citedOpen Access
Promoter hijacking by primate LINC00473 disrupts an ancestral CREB-PDE10A feedback loop
2025Open Access
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling
Science·2025· 4 cited
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Frequent Co-authors

Steven P. Gygi(34), J. Wade Harper(19), Edward L. Huttlin(10), Alban Ordureau(9), Laura Pontano Vaites(8), Devin K. Schweppe(7), John Szpyt(5), Ramin Rad(5), Brian K. Erickson(5), José Navarrete-Perea(5), Jin‐Mi Heo(4), Mark P. Jedrychowski(4), Jiaming Li(4), Raphael J. Bruckner(3), Joe R. Cannon(3), Kurt Baltier(3), Fana Gebreab(3), Melanie P. Gygi(3), Stanley Tam(3), Gabriela Zárraga-Granados(3)