Carl O. Pabo

Harvard University Press — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

66h-index26.6kcitations104works0.02yr avg
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Research Topics

RNA and protein synthesis mechanisms(37), Genomics and Chromatin Dynamics(32), DNA and Nucleic Acid Chemistry(27), RNA Research and Splicing(15), Monoclonal and Polyclonal Antibodies Research(15)

Publications104 total

An improved zinc-finger nuclease architecture for highly specific genome editing
Nature Biotechnology·2007· 1.0k cited
Specificity by design
Nature Biotechnology·2006· 2 cited
787. Engineered Fok I Heterodimers for Enhanced Zinc Finger Nuclease Specificity
Molecular Therapy·2006· 1 citedOpen Access
Pharmacological analysis of CCK2 receptors up-regulated using engineered transcription factors
Regulatory Peptides·2005· 7 cited
Allosteric Inhibition of Zinc-Finger Binding in the Major Groove of DNA by Minor-Groove Binding Ligands
Biochemistry·2004· 31 cited
Cell Lines for Drug Discovery: Elevating Target-Protein Levels Using Engineered Transcription Factors
SLAS DISCOVERY·2004· 12 citedOpen Access
Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors.
PubMed·2003· 71 cited
Engineered Zinc Finger Proteins for Controlling Stem Cell Fate
Stem Cells·2003· 56 citedOpen Access
Structure of a Designed Dimeric Zinc Finger Protein Bound to DNA <sup>,</sup>
Biochemistry·2003· 42 cited
Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection
Proceedings of the National Academy of Sciences·2003· 147 citedOpen Access
Zinc-finger protein-targeted gene regulation: Genomewide single-gene specificity
Proceedings of the National Academy of Sciences·2003· 150 citedOpen Access
Constraints for Zinc Finger Linker Design as Inferred from X-ray Crystal Structure of Tandem Zif268–DNA Complexes
Journal of Molecular Biology·2003· 38 cited
Drug discovery with engineered zinc-finger proteins
Nature Reviews Drug Discovery·2003· 267 cited
Gene-Specific Targeting of H3K9 Methylation Is Sufficient for Initiating Repression In Vivo
Current Biology·2002· 267 citedOpen Access
Crystal Structure of a Zif23-GCN4 Chimera Bound to DNA
2002
Rearrangement of side-chains in a zif268 mutant highlights the complexities of zinc finger-DNA recognition
Journal of Molecular Biology·2001· 68 cited
Beyond the “Recognition Code”
Structure·2001· 117 citedOpen Access
Zif268 D20A mutant bound to the GCT DNA site
2001
Zif268 D20A Mutant Bound to WT DNA Site
2001
Selected peptide extension contacts hydrophobic patch on neighboring zinc finger and mediates dimerization on DNA.
Nature Structural Biology·2001· 32 cited
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Frequent Co-authors

Robert T. Sauer(10), Mark A. Rould(8), Nikola P. Pavletich(4), Lena Nekludova(4), Alan D. Frankel(3), Philip D. Gregory(3), Scot A. Wolfe(3), Alexander D. Johnson(3), Mark Ptashne(3), Ernest Fraenkel(3), Jeffrey C. Miller(2), Dmitry Guschin(2), Ya-Li Lee(2), Edward J. Rebar(2), Charles R. Kissinger(2), Beishan Liu(2), Kristen A Chambers(2), Mitchell Lewis(2), Juli D. Klemm(2), Andrea Jeffrey(2)