Edward J. Rebar

Sana Biotechnology (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

52h-index22.0kcitations116works3.02yr avg
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Research Topics

CRISPR and Genetic Engineering(77), CAR-T cell therapy research(18), Advanced biosensing and bioanalysis techniques(16), Virus-based gene therapy research(15), RNA Interference and Gene Delivery(15)

Publications116 total

In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles
Nature Biotechnology·2025· 4 cited
Enabling Potent T Cell Delivery and Mitigating Key Off-Target Concerns of <i>In Vivo</i> CAR T Lentiviral Vectors with the Targeted Paramyxovirus Fusogen System
Blood·2024· 2 cited
Efficient and Specific <i>In Vivo</i> Genetic Engineering of Human Hematopoietic Stem Progenitor Cells without Selective Conditioning
Blood·2023Open Access
Efficient and Specific Multi-Locus Editing of Allogeneic CAR T Cells for Hypoimmunity during Large Scale Manufacture Using Cas12b
Blood·2022· 1 cited
Abstract 5598: Engineered hypoimmune allogeneic CAR T cells as potential off-the-shelf CAR T cell immunotherapies
Cancer Research·2022
Engineered Hypoimmune Allogeneic CAR T Cells Exhibit Innate and Adaptive Immune Evasion Even after Sensitization in Humanized Mice and Retain Potent Anti-Tumor Activity
Blood·2021· 5 cited
Abstract LB144: Overexpression of CD47 protects hypoimmune CAR T cells from innate immune cell killing
Cancer Research·2021· 5 cited
Persistent repression of tau in the brain using engineered zinc finger protein transcription factors
Science Advances·2021· 72 citedOpen Access
Enhancing gene editing specificity by attenuating DNA cleavage kinetics
Nature Biotechnology·2019· 60 cited
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease
Nature Medicine·2019· 212 cited
Diversifying the structure of zinc finger nucleases for high-precision genome editing
Nature Communications·2019· 126 citedOpen Access
Gene editing of the multi-copy H2A.B gene and its importance for fertility
Genome biology·2019· 38 citedOpen Access
Additional file 19: of Gene editing of the multi-copy H2A.B gene and its importance for fertility
Figshare·2019Open Access
Additional file 22: of Gene editing of the multi-copy H2A.B gene and its importance for fertility
Figshare·2019Open Access
Additional file 25: of Gene editing of the multi-copy H2A.B gene and its importance for fertility
Figshare·2019Open Access
Additional file 21: of Gene editing of the multi-copy H2A.B gene and its importance for fertility
Figshare·2019Open Access
Additional file 27: of Gene editing of the multi-copy H2A.B gene and its importance for fertility
Figshare·2019Open Access
Additional file 23: of Gene editing of the multi-copy H2A.B gene and its importance for fertility
Figshare·2019Open Access
Additional file 28: of Gene editing of the multi-copy H2A.B gene and its importance for fertility
Figshare·2019Open Access
Additional file 26: of Gene editing of the multi-copy H2A.B gene and its importance for fertility
Figshare·2019Open Access
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Frequent Co-authors

Philip D. Gregory(36), Fyodor D. Urnov(27), Jeffrey C. Miller(27), Michael C. Holmes(19), David E. Paschon(15), Dmitry Guschin(11), Xiangdong Meng(10), Bryan Zeitler(10), Sarah J. Hinkley(9), Lei Zhang(8), Gregory J. Cost(7), Yannick Doyon(7), Andreas Reik(7), David A. Shivak(7), Rudolf Jaenisch(6), Russell C. DeKelver(6), Lei Zhang(6), Stephen C.-T. Lam(6), Rainier Amora(6), Jianbin Wang(5)