David E. Paschon

Sangamo BioSciences (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index6.8kcitations43works8.02yr avg
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Research Topics

CRISPR and Genetic Engineering(31), Virus-based gene therapy research(15), CAR-T cell therapy research(9), RNA Interference and Gene Delivery(8), Advanced biosensing and bioanalysis techniques(6)

Publications43 total

Reprogrammed Serine Integrases Enable Precise Integration of Synthetic DNA
2024· 8 citedOpen Access
Enhancing gene editing specificity by attenuating DNA cleavage kinetics
Nature Biotechnology·2019· 60 cited
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease
Nature Medicine·2019· 212 cited
Diversifying the structure of zinc finger nucleases for high-precision genome editing
Nature Communications·2019· 126 citedOpen Access
Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1 <sup>+</sup> and TIGIT <sup>+</sup> CD4 T Cells
Journal of Virology·2019· 27 citedOpen Access
Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets
Molecular Therapy·2019· 87 citedOpen Access
Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity
Stem Cells Translational Medicine·2018· 12 citedOpen Access
COMPOSITIONS POUR LIER DES DOMAINES DE LIAISON À L'ADN ET DES DOMAINES DE CLIVAGE
2017
A7 Drug discovery approach for rare neurological diseases: using novel zinc finger protein technology to develop potential therapy for huntington’s disease
Journal of Neurology Neurosurgery & Psychiatry·2016· 1 cited
Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects
Stem Cell Reports·2016· 46 citedOpen Access
641. Highly Efficient, ZFN-Driven Knockout of Surface Expression of the T-Cell Receptor and HLA Class I Proteins in Human T-Cells for Enhancing Allogeneic Adoptive Cell Therapies
Molecular Therapy·2016· 1 citedOpen Access
Targeted gene addition in human CD34+ hematopoietic cells for correction of X-linked chronic granulomatous disease
Nature Biotechnology·2016· 191 citedOpen Access
Mammalian interspecies substitution of immune modulatory alleles by genome editing
Scientific Reports·2016· 109 citedOpen Access
In Vivo Genome Editing in Neonatal Mouse Liver Preferentially Utilizes Homology Directed Repair
Blood·2015· 1 cited
ZFN-Mediated Gene Targeting at the Albumin Locus in Liver Results in Therapeutic Levels of Human FIX in Mice and Non-Human Primates
Blood·2015· 4 cited
Functional footprinting of regulatory DNA
Nature Methods·2015· 137 citedOpen Access
In vivo genome editing of the albumin locus as a platform for protein replacement therapy
Blood·2015· 295 citedOpen Access
Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma
Molecular Therapy·2015· 111 citedOpen Access
185. Targeted Correction and Restored Function of CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells
Molecular Therapy·2015· 3 citedOpen Access
115. Correction of the Sickle-Cell Disease Mutation in Human Hematopoietic Stem/Progenitor Cells
Molecular Therapy·2015· 2 citedOpen Access
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Frequent Co-authors

Philip D. Gregory(30), Edward J. Rebar(27), Michael C. Holmes(25), Jeffrey C. Miller(17), Andreas Reik(14), Fyodor D. Urnov(13), Sarah J. Hinkley(8), Yannick Doyon(8), Dmitry Guschin(8), David A. Shivak(7), Xavier M. Anguela(6), Rajiv P. Sharma(6), Shangzhen Zhou(6), Katherine A. High(6), Matthew Mendel(6), Lei Zhang(6), Danny F. Xia(5), Xiangdong Meng(5), Stephen C.-T. Lam(5), Yuanyue Zhou(5)