Rudolf Jaenisch

Whitehead Institute for Biomedical Research — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

208h-index192.9kcitations802works7.32yr avg
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Research Topics

Pluripotent Stem Cells Research(226), CRISPR and Genetic Engineering(223), Epigenetics and DNA Methylation(127), Animal Genetics and Reproduction(92), Renal and related cancers(70)

Publications802 total

A human blood-brain barrier model reveals pericytes as critical regulators of viral neuroinvasion
iScience·2025Open Access
Human iPSC‐Derived Microglia Integrate Into Cerebral Organoids and Assume an In Vivo‐Like Phenotype
European Journal of Neuroscience·2025· 1 citedOpen Access
Author response for "Human iPSC-derived microglia integrate into cerebral organoids and assume an in vivo-like phenotype"
2025
Oxidative Stress and Interferon Signaling Drive Differential Pathogenesis of Ancestral and Contemporary Zika Viruses in Human Cerebral Organoids
2025· 1 citedOpen Access
Functional genomic dissection of MS risk loci reveals convergence of cis and trans gene regulatory mechanisms in microglia
2025Open Access
Exploring the complexity of MECP2 function in Rett syndrome
Nature reviews. Neuroscience·2025· 13 cited
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions
Neuron·2025Open Access
A novel human blood-brain barrier model reveals pericytes as critical regulators of viral neuroinvasion
2025Open Access
Rett Syndrome: Thinking Beyond Brain Borders
Advances in experimental medicine and biology·2025· 2 cited
SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection
Nature Communications·2024· 4 citedOpen Access
Heritable Immunization Establishes a New Model for Pathogen Control
2024
Epigenomics and single cell CRISPR screening to investigate the risk‐modifying role of microglia in Alzheimer’s disease and multiple sclerosis
Alzheimer s & Dementia·2024· 1 citedOpen Access
Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death
2024· 1 citedOpen Access
Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death
2024Open Access
Tuning porosity of macroporous hydrogels enables rapid rates of stress relaxation and promotes cell expansion and migration
Proceedings of the National Academy of Sciences·2024· 34 citedOpen Access
Abortive infection of bat fibroblasts with SARS-CoV-2
Proceedings of the National Academy of Sciences·2024· 5 citedOpen Access
Pharmacological inhibition of Fms-like kinase 3 (FLT3) promotes neuronal maturation and suppresses seizure in a mouse model
2024Open Access
Mitochondrial dysfunction and increased reactive oxygen species production in MECP2 mutant astrocytes and their impact on neurons
Scientific Reports·2024· 16 citedOpen Access
Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes
Immunity·2024· 5 cited
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions
Neuron·2024· 22 citedOpen Access
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Frequent Co-authors

Richard A. Young(11), Marius Wernig(9), B Bernstein(6), Jacob H. Hanna(6), Alexander Meissner(6), Tarjei S. Mikkelsen(5), Eric S. Lander(5), Laurie A. Boyer(5), Stuart S. Levine(5), Caroline Beard(5), Tong Ihn Lee(4), Matthew G. Guenther(4), Haoyi Wang(4), Tobias Brambrink(4), George W. Bell(4), Michael A. Rudnicki(4), Qing Gao(4), Kathrin Plath(3), Megan F. Cole(3), Sarah E. Johnstone(3)