Richard A. Young

Whitehead Institute for Biomedical Research — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

158h-index112.4kcitations549works9.12yr avg
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Research Topics

Genomics and Chromatin Dynamics(158), RNA Research and Splicing(107), Epigenetics and DNA Methylation(67), Protein Degradation and Inhibitors(63), RNA modifications and cancer(59)

Publications548 total

High‐throughput CRISPR screen of GWAS risk loci in human microglia reveals novel risk genes for Alzheimer's disease and multiple sclerosis
Alzheimer s & Dementia·2025Open Access
Social Factors and Chronic Disease Burden of Adults with Autism Spectrum Disorder in Multi-system Family Medicine Clinics
Big Data·2025Open Access
Transient gene melting governs the timing of oligodendrocyte maturation
Cell·2025· 2 citedOpen Access
Functional genomic dissection of MS risk loci reveals convergence of cis and trans gene regulatory mechanisms in microglia
2025Open Access
CRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs
Blood·2025· 3 citedOpen Access
Exploring the complexity of MECP2 function in Rett syndrome
Nature reviews. Neuroscience·2025· 13 cited
Epigenomics and single cell CRISPR screening to investigate the risk‐modifying role of microglia in Alzheimer’s disease and multiple sclerosis
Alzheimer s & Dementia·2024· 1 citedOpen Access
Proteolethargy is a pathogenic mechanism in chronic disease
Cell·2024· 21 citedOpen Access
Intellectual Disability (ID) and Chronic Conditions Burden among Adults : Insights from Harmonized Electronic Health Records
The Annals of Family Medicine·2024Open Access
Intensity of medication review activities in private and public clinics
The Annals of Family Medicine·2024Open Access
RNA and condensates: Disease implications and therapeutic opportunities
Cell chemical biology·2024· 33 citedOpen Access
MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons
Neuron·2024· 45 cited
203 RNA Polymerase II Meningioma Mutations Activate Forebrain Neurodevelopmental Pathways
Neurosurgery·2024
TIF1γ Counteracts Ferroptosis to Drive Erythroid Progenitor Differentiation
Blood·2023
Author Correction: Distinct chemical environments in biomolecular condensates
Nature Chemical Biology·2023· 3 citedOpen Access
Distinct chemical environments in biomolecular condensates
Nature Chemical Biology·2023· 94 citedOpen Access
Regulatory architecture of cell identity genes and housekeeping genes
Trends in Cell Biology·2023· 5 citedOpen Access
Transcription factors interact with RNA to regulate genes
Molecular Cell·2023· 234 citedOpen Access
Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state
Journal of Clinical Investigation·2023· 12 citedOpen Access
Regulatory architecture of housekeeping genes is driven by promoter assemblies
Cell Reports·2023· 45 citedOpen Access
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Frequent Co-authors

Tong Ihn Lee(18), Nancy M. Hannett(12), Rudolf Jaenisch(11), Stuart S. Levine(9), David K. Gifford(9), Peter B. Rahl(8), Phillip A. Sharp(7), Julia Zeitlinger(7), Brian J. Abraham(7), Ezra G. Jennings(6), Thomas L. Volkert(6), James E. Bradner(6), Laurie A. Boyer(5), Nicola J. Rinaldi(5), Duncan T. Odom(5), Christopher Harbison(5), Ernest Fraenkel(5), Denes Hnisz(5), George W. Bell(5), Eric S. Lander(5)