Phillip A. Sharp

Allen Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

173h-index125.3kcitations633works15.82yr avg
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Research Topics

RNA Research and Splicing(198), RNA and protein synthesis mechanisms(139), Virus-based gene therapy research(108), RNA modifications and cancer(93), RNA Interference and Gene Delivery(79)

Publications571 total

Engineered prime editors with minimal genomic errors
Nature·2025· 11 citedOpen Access
Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer
Immunity·2025· 13 citedOpen Access
RNA Dynamics Regulate Transcriptional Condensate Vivacity to Drive Gene Coordination
2025· 1 citedOpen Access
Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer
2024· 1 citedOpen Access
Engineered prime editors with minimal genomic errors
2024· 1 citedOpen Access
Single-cell nascent RNA sequencing unveils coordinated global transcription
Nature·2024· 86 citedOpen Access
Abstract B087: Mutant-p53 amplifies Cxcl1 expression from distal enhancers blunting immune checkpoint inhibition efficacy in pancreatic cancer
Cancer Research·2024
Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing
Genome biology·2024· 13 citedOpen Access
1517 Mutant-p53 amplifies Cxcl1 expression from distal enhancers blunting immune checkpoint inhibition efficacy in pancreatic cancer
2023Open Access
Correction for Song et al., “Sustained Small Interfering RNA-Mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages”
Journal of Virology·2023Open Access
Single-cell nascent RNA sequencing using click-chemistry unveils coordinated transcription
2023· 4 citedOpen Access
Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing
2023· 1 citedOpen Access
RNA Splicing—Cutting and Pasting Genes
Frontiers for Young Minds·2023Open Access
Oncogenic <i>CDK13</i> mutations impede nuclear RNA surveillance
Science·2023· 48 citedOpen Access
Supplementary Table 5 from The Octamer Binding Transcription Factor Oct-1 Is a Stress Sensor
2023Open Access
Supplementary Table 4 from The Octamer Binding Transcription Factor Oct-1 Is a Stress Sensor
2023Open Access
Data from The Octamer Binding Transcription Factor Oct-1 Is a Stress Sensor
2023Open Access
Supplementary Table 3 from The Octamer Binding Transcription Factor Oct-1 Is a Stress Sensor
2023Open Access
Supplementary Table 2 from The Octamer Binding Transcription Factor Oct-1 Is a Stress Sensor
2023Open Access
Data from The Octamer Binding Transcription Factor Oct-1 Is a Stress Sensor
2023Open Access
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Frequent Co-authors

Richard A. Young(7), Feng Zhang(4), Margaret S. Ebert(4), Carl D. Novina(4), Rudolf Jaenisch(3), Arnold Berk(3), David P. Bartel(3), Krishna Shrinivas(3), Nancy M. Hannett(3), Joel R. Neilson(3), Sidi Chen(3), Derek M. Dykxhoorn(3), Tyler Jacks(3), Harinder Singh(3), David Baltimore(3), Garrett M. Frampton(2), David Scott(2), Ophir Shalem(2), Phillip D. Zamore(2), Thomas Tuschl(2)