Tyler Jacks

Howard Hughes Medical Institute — United States

Medicine · Health Sciences

157h-index124.6kcitations813works11.62yr avg
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Research Topics

Cancer-related Molecular Pathways(139), Cancer Research and Treatments(80), Cancer Genomics and Diagnostics(77), RNA modifications and cancer(68), Chromatin Remodeling and Cancer(61)

Publications813 total

Malignant cell MHC-II immunopeptidomes reveal the evolution of tumor-host interactions
2025Open Access
MHC-II antigen presentation on cancer cells improves CD4+ T cell immunity and vaccine efficacy
2025Open Access
Clonal hematopoiesis and lung adenocarcinoma pathogenesis
Blood·2025
1280 Lung cancer cells sample local and systemic sources for MHC-II presentation
Regular and Young Investigator Award Abstracts·2025Open Access
Expanding the antigen repertoire in pancreatic cancer 4599
The Journal of Immunology·2025Open Access
Abstract A045: Pancreatic cancer-associated systemic nutrient starvation elevates autophagic proteolysis in the muscle
Cancer Research·2025
GLIS3 Marks a Neural-like Progenitor Cell State that Drives Metastasis in Pancreatic Ductal Adenocarcinoma
2025Open Access
The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancer
2025Open Access
Lineage identity governs oncogene dependence in murine NSCLC models of KRAS inhibitor resistance
2025Open Access
Multimodal profiling of proinflammatory protease activity identifies caspase-1 as a target for lung cancer interception
2025Open Access
Retraction notice to “Efficacy of Sunitinib and Radiotherapy in Genetically Engineered Mouse Model of Soft-Tissue Sarcoma” Int J Radiat Oncol Biol Phys, 2009; 74(4), pp 1207-1216
International Journal of Radiation Oncology*Biology*Physics·2025Open Access
Pancreatic cancer–restricted cryptic antigens are targets for T cell recognition
Science·2025· 33 cited
Abstract LB475: Capture the early benign-to-malignant transition of colon cancer in the mouse
Cancer Research·2025
A tissue-scale strategy for sensing threats in barrier organs
2025Open Access
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma
Cancer Cell·2025· 1 citedOpen Access
Intrinsic electrical activity drives small-cell lung cancer progression
Nature·2025· 29 citedOpen Access
Conditional fusogenic lipid nanocarriers for cytosolic delivery of macromolecular therapeutics
2024· 2 citedOpen Access
Abstract PR016: Early changes to the colon tumor microenvironment during benign-to- malignant transition
Cancer Research·2024
1369 Engineering approaches to exploit MHC-II presentation on lung cancer cells
Regular and Young Investigator Award Abstracts·2024Open Access
Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumour growth and metastasis
2024· 18 citedOpen Access
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Frequent Co-authors

Roderick T. Bronson(12), Denise Crowley(9), David A. Tuveson(7), Scott W. Lowe(5), Earlene M. Schmitt(4), Lee Ann Remington(4), Nicholas A. Willis(4), Kim L. Mercer(4), Andrea Ventura(4), Phillip A. Sharp(4), Rudolf Jaenisch(3), Eric S. Lander(3), David E. Housman(3), Erica L. Jackson(3), Robert A. Weinberg(3), Arjun Bhutkar(3), Thales Papagiannakopoulos(3), Jun Lü(2), E. Alejandro Sweet‐Cordero(2), Todd R. Golub(2)