Earlene M. Schmitt

Baylor College of Medicine — United States

Medicine · Health Sciences

15h-index10.2kcitations22works0.02yr avg
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Research Topics

Cancer-related Molecular Pathways(5), Ubiquitin and proteasome pathways(4), RNA modifications and cancer(3), Protein Tyrosine Phosphatases(3), Neuroblastoma Research and Treatments(3)

Publications22 total

MIF-CD74 signaling drives immune modulation in medulloblastoma
Neuro-Oncology·2026Open Access
An Animal Model of MYC-Driven Medulloblastoma
UNC Libraries·2020· 16 citedOpen Access
Tumor progression and chromatin landscape of lung cancer are regulated by the lineage factor GATA6
Oncogene·2020· 18 citedOpen Access
Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer
Nature Medicine·2018· 83 cited
Abstract 738: Combined inhibition of non-canonical HER2 signaling as a strategy to overcome resistance to HER2-targeted therapies
Cancer Research·2015
112 Genfome-wide shRNA Screening Defines the SUMO-activating Enzyme (SAE1/2) as a Novel Therapeutic Target for Tumors Driven by c-Myc Oncogenesis
Neurosurgery·2012· 1 cited
Abstract 3091: A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
Cancer Research·2012· 8 cited
An Animal Model of MYC-Driven Medulloblastoma
Cancer Cell·2012· 310 citedOpen Access
A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis
Science·2011· 434 citedOpen Access
Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase
Cell·2011· 274 citedOpen Access
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo
Proceedings of the National Academy of Sciences·2011· 701 cited
Abstract S6-10: Identification of a Novel Tumor Suppressor Network Reveals a Role for Proto-Oncogenic Receptor Tyrosine Kinases in Triple-Negative Breast Cancer
Cancer Research·2010
SUMOylation of the transcription factor NFATc1 leads to its subnuclear relocalization and IL2 repression by HDAC
Cell Communication and Signaling·2009Open Access
Mouse Models of Tumor Development in Neurofibromatosis Type 1
Science·1999· 469 cited
A multidrug-resistance protein (MRP)-like transmembrane pump is highly expressed by resting murine T helper (Th) 2, but not Th1 cells, and is induced to equal expression levels in Th1 and Th2 cells after antigenic stimulation in vivo.
Journal of Clinical Investigation·1998· 42 citedOpen Access
Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.
The EMBO Journal·1994· 286 citedOpen Access
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
Nature Genetics·1994· 771 cited
Tumor spectrum analysis in p53-mutant mice
Current Biology·1994· 2.1k cited
p53 is required for radiation-induced apoptosis in mouse thymocytes
Nature·1993· 2.9k cited
Effects of an Rb mutation in the mouse
Nature·1992· 1.8k cited
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Frequent Co-authors

Thomas F. Westbrook(9), Rachel Schiff(7), Tyler Jacks(6), Jessica D. Kessler(6), Tingting Sun(6), Roderick T. Bronson(5), Kristen L. Meerbrey(5), Ronald J. Bernardi(5), Mitchell Rao(5), Rocío Domínguez-Vidaña(5), C. Kent Osborne(5), Susan G. Hilsenbeck(5), Chad A. Shaw(5), Mamie Z. Li(4), Stephen J. Elledge(4), Chad J. Creighton(4), Robert A. Weinberg(3), Kristopher T. Kahle(3), Michael R. Schlabach(3), Samuel O. Skinner(3)