Phillip D. Zamore

Howard Hughes Medical Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

93h-index50.1kcitations234works5.02yr avg
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Research Topics

RNA Research and Splicing(69), RNA Interference and Gene Delivery(69), CRISPR and Genetic Engineering(68), Chromosomal and Genetic Variations(64), MicroRNA in disease regulation(62)

Publications234 total

Cleavage of mRNAs by a minority of pachytene piRNAs improves sperm fitness
Nature·2026Open Access
Biochemical principles of miRNA targeting in flies
Nature Communications·2026Open Access
Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis
Cell Reports·2025· 3 citedOpen Access
Piwi and piRNAs repress transcription of aberrant rRNA genes containing retrotransposon fragments
2025Open Access
Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis
2025Open Access
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals
Nature Reviews Molecular Cell Biology·2025· 30 citedOpen Access
Biochemical principles of miRNA targeting in flies
2024· 2 citedOpen Access
Mouse Pachytene piRNAs Cleave Hundreds of Transcripts, But Alter the Steady-State Abundance of Only a Minority of Targets
2024· 5 citedOpen Access
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila
Nature Cell Biology·2023· 13 citedOpen Access
Relaxed targeting rules help PIWI proteins silence transposons
Nature·2023· 87 citedOpen Access
Protocol to measure protein-RNA binding using double filter-binding assays followed by phosphorimaging or high-throughput sequencing
STAR Protocols·2023· 7 citedOpen Access
The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice
Reproduction·2022· 23 citedOpen Access
A-MYB/TCFL5 regulatory architecture ensures the production of pachytene piRNAs in placental mammals
RNA·2022· 25 citedOpen Access
Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB
Molecular Cell·2022· 54 citedOpen Access
<i>Drosophila</i> Males Use 5′-to-3′ Phased Biogenesis to Make <i>Stellate</i> -silencing piRNAs that Lack Homology to Maternally Deposited piRNA Guides
2022· 1 citedOpen Access
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors
The CRISPR Journal·2022· 49 citedOpen Access
Relaxed targeting rules allow PIWI-clade Argonaute proteins to silence ever-mutating transposons
2022· 3 citedOpen Access
GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins
Nature·2022· 60 citedOpen Access
Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing
ACS Chemical Biology·2022· 8 citedOpen Access
Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB
2022· 4 citedOpen Access
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Frequent Co-authors

Zhiping Weng(8), Chengjian Li(7), Yukihide Tomari(7), György Hutvàgner(6), Tingting Du(6), Benjamin Haley(6), Jia Xu(6), David P. Bartel(5), Hervé Seitz(5), Michael D. Horwich(5), Megha Ghildiyal(4), Vasily V. Vagin(4), William E. Theurkauf(4), Dianne S. Schwarz(3), Thomas Tuschl(3), Christian B. Matranga(3), Ruth Lehmann(3), Soohyun Lee(3), Carla Klattenhoff(3), Neil Aronin(2)