David Scott

Biochemistry, Genetics and Molecular Biology · Life Sciences

42h-index41.2kcitations91works3.72yr avg
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Research Topics

CRISPR and Genetic Engineering(37), DNA Repair Mechanisms(17), RNA and protein synthesis mechanisms(14), Advanced biosensing and bioanalysis techniques(11), Carcinogens and Genotoxicity Assessment(11)

Publications78 total

Structural basis for target DNA cleavage and guide RNA processing by CRISPR-Casλ2
Communications Biology·2025· 4 citedOpen Access
Initial Characterization of 12 New Subtypes and Variants of Type V CRISPR Systems
The CRISPR Journal·2025· 7 cited
Structural basis for target DNA cleavage and guide RNA processing by CRISPR-Casλ2
2025Open Access
Serine-129 phosphorylation of α-synuclein is a trigger for physiologic protein-protein interactions and synaptic function
2022· 5 citedOpen Access
The miniature CRISPR-Cas12m effector binds DNA to block transcription
Molecular Cell·2022· 91 citedOpen Access
Engineered Cas12i2 is a versatile high-efficiency platform for therapeutic genome editing
Nature Communications·2022· 46 citedOpen Access
Structure of the type V-C CRISPR-Cas effector enzyme
Molecular Cell·2022· 40 citedOpen Access
The Miniature CRISPR-Cas12m Effector Binds DNA To Block Transcription
SSRN Electronic Journal·2021· 11 citedOpen Access
Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants
Nature Reviews Microbiology·2019· 2.4k citedOpen Access
A Survey of Genome Editing Activity for 16 Cas12a Orthologs
The Keio Journal of Medicine·2019· 77 citedOpen Access
Breaks Labeling in situ and sequencing (BLISS)
2019· 2 citedOpen Access
CRISPR–Cas in mobile genetic elements: counter-defence and beyond
Nature Reviews Microbiology·2019· 273 citedOpen Access
Erratum: Tang et al., “Fast Vesicle Transport Is Required for the Slow Axonal Transport of Synapsin”
Journal of Neuroscience·2019Open Access
Erratum: Battal et al., “Representation of Auditory Motion Directions and Sound Source Locations in the Human Planum Temporale”
Journal of Neuroscience·2019Open Access
GCMS files for Pathria et al., Nat Cell Biol 2019
Figshare·2019Open Access
Functionally diverse type V CRISPR-Cas systems
Science·2018· 509 citedOpen Access
Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein
Molecular Cell·2018· 476 citedOpen Access
Cancer’s toughest challenges: a new call to the physical sciences
Convergent Science Physical Oncology·2017Open Access
Implications of human genetic variation in CRISPR-based therapeutic genome editing
Nature Medicine·2017· 127 citedOpen Access
BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks
Nature Communications·2017· 379 citedOpen Access
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Frequent Co-authors

Feng Zhang(16), Winston X. Yan(12), Jonathan S. Gootenberg(8), Bernd Zetsche(8), Kira S. Makarova(8), Eugene V. Koonin(8), Patrick D. Hsu(5), David R. Cheng(5), John van der Oost(5), Omar O. Abudayyeh(5), H.J. Evans(5), F. Ann Ran(4), Silvana Konermann(4), Alexandro E. Trevino(4), Prarthana Mohanraju(4), Wen Y. Wu(4), Ophir Shalem(3), Phillip A. Sharp(3), Linyi Gao(3), Sergey Shmakov(3)