Denes Hnisz

Max Planck Institute for Molecular Genetics — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index21.1kcitations77works9.82yr avg
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Research Topics

Genomics and Chromatin Dynamics(42), RNA Research and Splicing(30), RNA and protein synthesis mechanisms(13), RNA modifications and cancer(13), Epigenetics and DNA Methylation(12)

Publications77 total

Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule
Science Advances·2026Open Access
BoltzGen: Toward Universal Binder Design
2025· 10 citedOpen Access
Single-cell activation screen identifies hepatic maturation regulators with zonal resolution
Developmental Cell·2025Open Access
Differential oligomerization regulates PHF13 chromatin affinity and function
Nucleic Acids Research·2025· 3 citedOpen Access
MYC-induced oncogenesis is dependent on acidic patches within its N-terminal intrinsically disordered domain
2025
Probing condensate microenvironments with a micropeptide killswitch
Nature·2025· 16 citedOpen Access
Transcription factor condensates: Preventing aggregation by DNA binding
Cell·2025
Oligomerization enables the selective targeting of intrinsically disordered regions by small molecules
2025· 5 citedOpen Access
Functional specificity in biomolecular condensates revealed by genetic complementation
Nature Reviews Genetics·2024· 31 cited
An activity-specificity trade-off encoded in human transcription factors
Nature Cell Biology·2024· 33 citedOpen Access
Rational optimization of a transcription factor activation domain inhibitor
Nature Structural & Molecular Biology·2023· 61 citedOpen Access
High-sensitive nascent transcript sequencing reveals BRD4-specific control of widespread enhancer and target gene transcription
Nature Communications·2023· 12 citedOpen Access
CEBPA phase separation links transcriptional activity and 3D chromatin hubs
Cell Reports·2023· 26 citedOpen Access
Regulatory architecture of housekeeping genes is driven by promoter assemblies
Cell Reports·2023· 45 citedOpen Access
Aberrant phase separation and nucleolar dysfunction in rare genetic diseases
Nature·2023· 139 citedOpen Access
T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation
eLife·2023· 4 citedOpen Access
Author response: T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation
2022Open Access
Aberrant phase separation and nucleolar dysfunction can underlie rare genetic diseases
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Aberrant phase separation and nucleolar dysfunction can underlie rare genetic diseases
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Discovery and characterization of <i>LNCSOX17</i> as an essential regulator in human endoderm formation
2022Open Access
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Frequent Co-authors

Richard A. Young(19), Brian J. Abraham(13), Abraham S. Weintraub(13), Tong Ihn Lee(12), Charles H. Li(7), Karl Kuchler(7), Daniel S. Day(6), Jurian Schuijers(6), Henri Niskanen(6), Carla Garcia‐Cabau(6), René Buschow(6), Xavier Salvatella(6), David Meierhofer(6), James E. Bradner(5), Julian Naderi(5), Rudolf Jaenisch(4), Shaon Basu(4), Sebastian D. Mackowiak(4), Alexander Meissner(4), Alexandre P. Magalhães(4)