Mitchell Lewis

University of Pennsylvania — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index5.6kcitations54works0.02yr avg
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Research Topics

Bacterial Genetics and Biotechnology(20), RNA and protein synthesis mechanisms(20), Protein Structure and Dynamics(11), Enzyme Structure and Function(10), DNA and Nucleic Acid Chemistry(9)

Publications54 total

Predictive shifts in free energy couple mutations to their phenotypic consequences
Proceedings of the National Academy of Sciences·2019· 46 citedOpen Access
The Energetics of Molecular Adaptation in Transcriptional Regulation
2019Open Access
Author Correction: An Autogenously Regulated Expression System for Gene Therapeutic Ocular Applications
Scientific Reports·2018Open Access
Tuning Transcriptional Regulation through Signaling: A Predictive Theory of Allosteric Induction
Cell Systems·2018· 112 citedOpen Access
A Predictive Theory of Allosteric Regulation in Transcription
Bulletin of the American Physical Society·2018
Tuning transcriptional regulation through signaling: A predictive theory\n of allosteric induction
arXiv (Cornell University)·2017Open Access
Tuning transcriptional regulation through signaling: A predictive theory of allosteric induction
2017Open Access
An Autogenously Regulated Expression System for Gene Therapeutic Ocular Applications
Scientific Reports·2015· 14 citedOpen Access
Allostery and the lac Operon
Journal of Molecular Biology·2013· 48 cited
Thermodynamic Analysis of Mutant lac Repressors
Journal of Molecular Biology·2011· 55 cited
A Tale of Two Repressors
Journal of Molecular Biology·2011· 44 cited
Functional rules for lac repressor–operator associations and implications for protein–DNA interactions
Protein Science·2010· 31 citedOpen Access
Towards evolving a better repressor
Protein Engineering Design and Selection·2009· 29 cited
One Is Not Enough
Journal of Molecular Biology·2009· 33 citedOpen Access
A Novel Molecular Switch
Journal of Molecular Biology·2009· 22 citedOpen Access
The bacteriophage λ CI protein finds an asymmetric solution
Current Opinion in Structural Biology·2009· 46 citedOpen Access
Crystal structure of the λ repressor and a model for pairwise cooperative operator binding
Nature·2008· 104 cited
Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators
BMC Genomics·2007· 43 citedOpen Access
Structural Analysis of Lac Repressor Bound to Allosteric Effectors
Journal of Molecular Biology·2007· 89 citedOpen Access
The Structural Basis of Cooperative Regulation at an Alternate Genetic Switch
Molecular Cell·2006· 33 citedOpen Access
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Frequent Co-authors

Steven E. Stayrook(9), T.M. Penning(7), Charles E. Bell(7), Robert Daber(6), Joseph M. Jez(4), Brian P. Schlegel(4), Carl O. Pabo(4), Ann Hochschild(4), Michele A. Kercher(3), Helen C. Pace(3), Ponzy Lu(3), M. J. Bennett(3), Caleb B. Kallen(3), Yi Jin(3), Manuel Razo‐Mejia(3), Stephanie L. Barnes(3), Nathan M. Belliveau(3), Griffin Chure(3), Tal Einav(3), Rob Phillips(3)