Scot A. Wolfe

Biochemistry, Genetics and Molecular Biology · Life Sciences

60h-index13.7kcitations172works4.12yr avg
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Research Topics

CRISPR and Genetic Engineering(90), RNA and protein synthesis mechanisms(26), Genomics and Chromatin Dynamics(23), Advanced biosensing and bioanalysis techniques(19), Virus-based gene therapy research(17)

Publications172 total

Testing a dual AAV gene therapy vector construct to treat sialidosis and galactosialidosis using small and large animal models
Molecular Genetics and Metabolism·2026
Modular Platform for Therapeutic Drug Delivery Using Trifunctional Bio-Orthogonal Macromolecular Conjugates
Bioconjugate Chemistry·2025
Efficient, potent, and specific near-universal base and prime editing for ELANE-mutant severe congenital neutropenia
Blood·2025
Efficient prime editing of human hematopoietic stem cells corrects the recurrent SBDS C.258+2T>C mutation and recovers engraftment potential in shwachman-diamond syndrome
Blood·2025
Evaluating the Impact of Normothermic Machine Perfusion on Liver Transplant Outcomes and Surgical Team Wellbeing
American Journal of Transplantation·2025
Reassessment of Biomarkers and Acceptance Criteria in Normothermic Machine Perfusion for Liver Allografts
American Journal of Transplantation·2025· 1 citedOpen Access
Modular platform for therapeutic drug delivery using trifunctional bio-orthogonal macromolecular conjugates
2025Open Access
Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell death
Nature Communications·2025· 4 citedOpen Access
Identifying optimal conditions for precise knock-in of exogenous DNA into the zebrafish genome
Development·2025· 3 citedOpen Access
Efficient Cas9 nuclease-based editing in skeletal muscle via lipid nanoparticle delivery
2025· 2 citedOpen Access
Direct delivery of Cas-embedded cytosine base editors as ribonucleoprotein complexes for efficient and accurate editing of clinically relevant targets
Nucleic Acids Research·2024· 2 citedOpen Access
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells
Cell stem cell·2024· 22 citedOpen Access
BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate
Cell stem cell·2024· 14 cited
The co-receptor Neuropilin-1 enhances proliferation in inv(16) acute myeloid leukemia via VEGF signaling
Leukemia·2024· 6 citedOpen Access
Increasing intracellular dNTP levels improves prime editing efficiency
Nature Biotechnology·2024· 18 citedOpen Access
Scalable assessment of genome editing off-targets associated with genetic variants
2024· 2 citedOpen Access
PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencing
2024· 1 citedOpen Access
Ex vivo culture resting time impacts transplantation outcomes of genome-edited human hematopoietic stem and progenitor cells in xenograft mouse models
Cytotherapy·2024· 3 citedOpen Access
Direct delivery of stabilized Cas-embedded base editors achieves efficient and accurate editing of clinically relevant targets
2024Open Access
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing <i>in vivo</i>
Nucleic Acids Research·2023· 14 citedOpen Access
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Frequent Co-authors

Lihua Julie Zhu(14), Nathan D. Lawson(10), Kevin Luk(10), Michael H. Brodsky(9), Ankit Gupta(8), Wen Xue(6), Pengpeng Liu(6), Daniel E. Bauer(6), Erik J. Sontheimer(6), Sneha Suresh(5), Mehmet Fatih Bolukbasi(5), Xiangdong Meng(5), Jing Zeng(5), Saurabh Sinha(5), Carl O. Pabo(4), Guangping Gao(4), Daniel G. Anderson(4), Luca Pinello(4), Shengdar Q. Tsai(4), Esther Mintzer(4)