Daniel E. Bauer

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

59h-index17.6kcitations224works10.12yr avg
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Research Topics

CRISPR and Genetic Engineering(92), Hemoglobinopathies and Related Disorders(70), Erythrocyte Function and Pathophysiology(29), Prenatal Screening and Diagnostics(23), RNA modifications and cancer(21)

Publications223 total

Modular Platform for Therapeutic Drug Delivery Using Trifunctional Bio-Orthogonal Macromolecular Conjugates
Bioconjugate Chemistry·2025
Efficient, potent, and specific near-universal base and prime editing for ELANE-mutant severe congenital neutropenia
Blood·2025
Hydroxyurea sequesters the histone methyltransferase G9a at stressed replication forks to reactivate fetal hemoglobin
Blood·2025Open Access
Apheresis blood processing with heparin improves stem cell collection outcomes for sickle cell gene therapy
Blood·2025
Efficient prime editing of human hematopoietic stem cells corrects the recurrent SBDS C.258+2T>C mutation and recovers engraftment potential in shwachman-diamond syndrome
Blood·2025
The XPO7-NPAT axis represents key vulnerabilities in <i>TP53</i> -mutated acute myeloid leukemia
Blood·2025· 1 citedOpen Access
Analyzing long-read CRISPR experiments with CRISPRLungo
2025Open Access
Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program
UNC Libraries·2025Open Access
In situ gene editing of hematopoietic stem cells via AAV-delivered CRISPR guide RNAs
Blood Advances·2025Open Access
Discovery of A Small Molecule non-IMiD Degrader of ZBTB7A for the Treatment of β-hemoglobinopathies
2025· 1 citedOpen Access
A xeno-free red blood cell differentiation formula models sickle cell disease from somatically sourced patient iPSCs
Experimental Hematology·2025· 1 cited
Direct and indirect regulation of fetal globin transcript by RNA-binding protein IGF2BP1
2025· 1 citedOpen Access
Modular platform for therapeutic drug delivery using trifunctional bio-orthogonal macromolecular conjugates
2025Open Access
CRISPR-based therapeutic genome editing for inherited blood disorders  
Nature Reviews Drug Discovery·2025· 6 cited
<i>In cellulo</i> DNA assembly for targeted genomic integration and rearrangement in human cells
2025· 2 citedOpen Access
Deciphering the role of non-coding sequence variants predisposing to pediatric B-ALL
Klinische Pädiatrie·2025
Direct delivery of Cas-embedded cytosine base editors as ribonucleoprotein complexes for efficient and accurate editing of clinically relevant targets
Nucleic Acids Research·2024· 2 citedOpen Access
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells
Cell stem cell·2024· 22 citedOpen Access
BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate
Cell stem cell·2024· 14 cited
RNA methylation controls stress granule formation and function during erythropoiesis
2024· 1 citedOpen Access
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Frequent Co-authors

Stuart H. Orkin(25), Luca Pinello(18), Matthew C. Canver(14), Jing Zeng(10), Guo‐Cheng Yuan(9), Scot A. Wolfe(7), Ryo Kurita(6), Yukio Nakamura(6), Jian Xu(6), Yuxuan Wu(6), Qiuming Yao(6), Kevin Luk(6), Mitchel A. Cole(5), Falak Sher(5), Takahiro Maeda(5), Christian Brendel(5), Kendell Clement(4), Craig B. Thompson(4), Divya S. Vinjamur(4), Guillaume Lettre(4)