Christian Brendel

Boston Children's Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

34h-index4.5kcitations156works4.32yr avg
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Research Topics

Virus-based gene therapy research(39), CRISPR and Genetic Engineering(32), CAR-T cell therapy research(26), Hemoglobinopathies and Related Disorders(21), RNA Interference and Gene Delivery(15)

Publications156 total

Efficient prime editing of human hematopoietic stem cells corrects the recurrent SBDS C.258+2T>C mutation and recovers engraftment potential in shwachman-diamond syndrome
Blood·2025
Modeling integration site data for safety assessment with MELISSA
Nature Communications·2025· 2 citedOpen Access
Have we really solved rAAV6 toxicity? A closer look at mannose-coupled rAAV6 vectors
Molecular Therapy — Nucleic Acids·2025Open Access
Correction: Weber et al. Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL Leukemia Cells. Cancers 2015, 7, 503–537
Cancers·2025Open Access
In vivo HSC Gene Therapy Using BaEVRLess-Pseudotyped Alpha-Retroviral and Lentiviral Vectors
SSRN Electronic Journal·2025Open Access
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells
Cell stem cell·2024· 22 citedOpen Access
Engineered packaging cell line for the enhanced production of baboon-enveloped retroviral vectors
Molecular Therapy — Nucleic Acids·2024· 4 citedOpen Access
Epitope Editing Combined with Extended Schedule Anti-KIT Antibody Treatment Allows Immune-Based In Vivo Selection of Multiplex Genome-Engineered Cells
Blood·2024Open Access
1140 Engineered B cells show anti-tumor activity in preclinical model of HER2+ breast cancer
Regular and Young Investigator Award Abstracts·2024· 1 citedOpen Access
Modeling integration site data for safety assessment with MELISSA
2024· 1 citedOpen Access
UM171 enhances fitness and engraftment of gene-modified hematopoietic stem cells from patients with sickle cell disease
Blood Advances·2024· 5 citedOpen Access
Scalable assessment of genome editing off-targets associated with genetic variants
2024· 2 citedOpen Access
Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes
Proceedings of the National Academy of Sciences·2024· 3 citedOpen Access
A novel high-titer, bifunctional lentiviral vector for autologous hematopoietic stem cell gene therapy of sickle cell disease
Molecular Therapy — Methods & Clinical Development·2024· 3 citedOpen Access
<i>Colloquium</i>: Topologically protected transport in engineered mechanical systems
Reviews of Modern Physics·2024· 26 cited
Abstract NG05: Epitope editing enables targeted immunotherapy of acute myeloid leukemia
Cancer Research·2024
Epitope Edited Hematopoietic Stem Cells to Enable Synergistic Immunotherapy Combinations for Acute Myeloid Leukemia
Blood·2023Open Access
Epitope Edited Hematopoietic Stem Cells Allow Immune-Based In Vivo Selection of Genome-Engineered Cells
Blood·2023Open Access
UM171 Enhances Fitness and Engraftment of Gene Modified Hematopoietic Stem Cells from Sickle Cells Disease Patients
Blood·2023· 1 cited
237 Epitope engineered hematopoietic stem cells to enable multi-specificity CAR-T cells for acute myeloid leukemia
Regular and Young Investigator Award Abstracts·2023· 1 citedOpen Access
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Frequent Co-authors

Manuel Grez(15), David A. Williams(9), Daniel E. Bauer(7), Axel Schambach(7), Linping Chen-Wichmann(7), Florian Marquardt(6), John Manis(5), Daniela Abriss(5), Adrian J. Thrasher(5), Vittorio Peano(5), Uta Müller-Kuller(5), Hana Kunkel(5), Kerstin B. Kaufmann(5), Jing Zeng(4), Erica B. Esrick(4), Myriam Armant(4), Denise Klatt(4), Stuart H. Orkin(4), Giorgia Santilli(4), Stefan Stein(4)