Adrian J. Thrasher

Great Ormond Street Hospital — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

107h-index44.3kcitations778works6.42yr avg
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Research Topics

Virus-based gene therapy research(267), CAR-T cell therapy research(153), CRISPR and Genetic Engineering(130), RNA Interference and Gene Delivery(101), Health, Medicine and Society(96)

Publications762 total

Unveiling the cut-and-repair cycle of designer nucleases in human stem and T cells via CLEAR-time dPCR
Nature Communications·2025Open Access
Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1
Obstetrical & Gynecological Survey·2025
Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency
New England Journal of Medicine·2025· 5 cited
A modified cyclosporine enhances lentivector transduction <i>ex vivo</i> and <i>in vivo</i> by degrading IFITM3
2025Open Access
Preclinical evaluation of lentiviral gene therapy for adenosine deaminase 2 deficiency (DADA2): engraftment efficiency and biodistribution in humanised NBSGW mice
Gene Therapy·2025Open Access
Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1
New England Journal of Medicine·2025· 8 cited
Ex vivo modification of hematopoietic stem and progenitor cells for gene therapy
Molecular Therapy·2025· 5 cited
Ex vivo T-lymphopoiesis assays assisting corrective treatment choice for genetically undefined T-lymphocytopenia
Clinical Immunology·2025· 1 citedOpen Access
Betibeglogene Autotemcel (Beti-cel) Gene Addition Therapy Results in Durable Hemoglobin A (HbA) Production with up to 10 Years of Follow-up in Participants with Transfusion-Dependent β-Thalassemia
Transplantation and Cellular Therapy·2025· 1 cited
Wiskott-Aldrich Syndrome and Cell Migration Defects
Elsevier eBooks·2025
Tailoring capsid-directed evolution technology for improved AAV-mediated CAR-T generation
Molecular Therapy·2024· 4 cited
Preclinical ex vivo IL2RG gene therapy using autologous hematopoietic stem cells as an effective and safe treatment for X-linked severe combined immunodeficiency disease
Genes & Diseases·2024· 6 citedOpen Access
Lentiviral-Mediated Gene Therapy for Patients with Fanconi Anemia [Group a]: Updated Results from Global RP-L102 Clinical Trials
Blood·2024· 2 citedOpen Access
Potent and Effective Targeting of AML with ‘Off-the-Shelf’ Engineered CD45-Targeting CAR T-Cells
Blood·2024· 3 citedOpen Access
Betibeglogene Autotemcel (beti-cel) Gene Addition Therapy Results in Durable Hemoglobin a Production with up to 10 Years of Follow-up with Transfusion-Dependent β-Thalassemia
Blood·2024· 2 cited
Betibeglogene autotemcel gene therapy in patients with transfusion-dependent, severe genotype β-thalassaemia (HGB-212): a non-randomised, multicentre, single-arm, open-label, single-dose, phase 3 trial
The Lancet·2024· 32 cited
Dominant negative variants in <i>ITPR3</i> impair T cell Ca2+ dynamics causing combined immunodeficiency
The Journal of Experimental Medicine·2024· 10 citedOpen Access
Lentiviral Gene Therapy for Cerebral Adrenoleukodystrophy
New England Journal of Medicine·2024· 59 citedOpen Access
Dietitian Collaboration with Interprofessional Continuing Education (IPCE) to Increase Interprofessional Education (IPE) on Total Parenteral Nutrition Management (TPN)
Journal of the Academy of Nutrition and Dietetics·2024Open Access
Alpharetroviral Vector–Mediated Gene Therapy for IL7RA-Deficient Severe Combined Immunodeficiency
Human Gene Therapy·2024· 3 cited
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Frequent Co-authors

Kimberly Gilmour(10), Christine Kinnon(10), Manfred Schmidt(10), H. Bobby Gaspar(10), Christof von Kalle(8), Alain Fischer(8), Marina Cavazzana(7), Siobhan O. Burns(7), Stuart Adams(6), Robin R. Ali(5), Steven J. Howe(5), Kathryn L. Parsley(5), Christine Rivat(5), Paul Veys(5), Dinakantha Kumararatne(5), Capucine Pïcard(5), Kerstin Schwarzwaelder(4), Manuel Grez(4), Waseem Qasim(4), Hans D. Ochs(4)