Kathryn L. Parsley

Great Ormond Street Hospital — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index3.7kcitations14works0.02yr avg
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Research Topics

Virus-based gene therapy research(10), CAR-T cell therapy research(9), RNA Interference and Gene Delivery(6), CRISPR and Genetic Engineering(3), T-cell and B-cell Immunology(2)

Publications14 total

Thymus transplantation for complete DiGeorge syndrome: European experience
Journal of Allergy and Clinical Immunology·2017· 132 citedOpen Access
X-SCID paper 2011
2014
Lack of T-cell responses following autologous tumour lysate pulsed dendritic cell vaccination, in patients with relapsed osteosarcoma
Clinical & Translational Oncology·2012· 71 citedOpen Access
Somatic Gene Therapy for X-Linked Severe Combined Immunodeficiency Using a Self-Inactivating Modified Gammaretroviral Vector Results in An Improved Preclinical Safety Profile and Early Clinical Efficacy in a Human Patient
Blood·2011· 5 cited
Hematopoietic Stem Cell Gene Therapy for Adenosine Deaminase–Deficient Severe Combined Immunodeficiency Leads to Long-Term Immunological Recovery and Metabolic Correction
Science Translational Medicine·2011· 281 citedOpen Access
Long-Term Persistence of a Polyclonal T Cell Repertoire After Gene Therapy for X-Linked Severe Combined Immunodeficiency
Science Translational Medicine·2011· 232 citedOpen Access
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming
Blood·2011· 74 citedOpen Access
Biochemical Correction of X-CGD by a Novel Chimeric Promoter Regulating High Levels of Transgene Expression in Myeloid Cells
Molecular Therapy·2010· 150 citedOpen Access
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
Journal of Clinical Investigation·2008· 1.3k citedOpen Access
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo
Journal of Clinical Investigation·2007· 203 citedOpen Access
Comparison of HIV- and EIAV-Based Vectors on Their Efficiency in Transducing Murine and Human Hematopoietic Repopulating Cells
Molecular Therapy·2005· 29 citedOpen Access
Failure of SCID-X1 gene therapy in older patients
Blood·2005· 128 citedOpen Access
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector
The Lancet·2004· 682 cited
High-Level Transduction and Gene Expression in Hematopoietic Repopulating Cells Using a Human Imunodeficiency Virus Type 1-Based Lentiviral Vector Containing an Internal Spleen Focus Forming Virus Promoter
Human Gene Therapy·2002· 487 cited

Frequent Co-authors

Adrian J. Thrasher(14), Kimberly Gilmour(9), Christine Kinnon(8), Steven J. Howe(6), H. Bobby Gaspar(6), Stuart Adams(5), Jinhua Bayford(5), Christof von Kalle(4), Samantha Cooray(4), E. Graham Davies(4), Martijn H. Brugman(3), Manfred Schmidt(3), Joanna Sinclair(3), Abdulaziz Al Ghonaium(3), Lucinda Brown(3), H. Bobby Gaspar(3), Kerstin Schwarzwaelder(2), Karin Pike‐Overzet(2), Dick de Ridder(2), Susannah I. Thornhill(2)