Karin Pike‐Overzet

Leiden University Medical Center — Netherlands

Medicine · Health Sciences

30h-index4.4kcitations77works1.52yr avg
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Research Topics

CAR-T cell therapy research(31), Virus-based gene therapy research(28), Immune Cell Function and Interaction(18), CRISPR and Genetic Engineering(15), Immunodeficiency and Autoimmune Disorders(10)

Publications77 total

RAG1 lentiviral gene therapy restores T-cell development of RAG1-SCID patient cells in artificial thymic organoids
Blood Advances·2025· 1 citedOpen Access
Safety and efficacy of gene therapy for RAG1-deficient SCID
Molecular Therapy·2025· 1 cited
The epigenetic reader MORC3 is required for T cell development in the thymus
2025Open Access
Utilizing epigenetic regulators to improve HSC-based lentiviral gene therapy
Blood Advances·2024· 4 citedOpen Access
Lentiviral Gene Therapy for Mucopolysaccharidosis II with Tagged Iduronate 2-Sulfatase Prevents Life-Threatening Pathology in Peripheral Tissues But Fails to Correct Cartilage
Human Gene Therapy·2023· 3 citedOpen Access
Partial correction of immunodeficiency by lentiviral vector gene therapy in mouse models carrying Rag1 hypomorphic mutations
Frontiers in Immunology·2023· 4 citedOpen Access
Single-Cell-Multiomics Demonstrates Molecular Efficacy of a Clinical Lentiviral Vector for Gene Therapy of RPS19-Deficient Diamond-Blackfan Anemia
Blood·2023· 1 cited
Tagged IDS causes efficient and engraftment-independent prevention of brain pathology during lentiviral gene therapy for Mucopolysaccharidosis type II
Molecular Therapy — Methods & Clinical Development·2023· 6 citedOpen Access
The recombinase activating genes: architects of immune diversity during lymphocyte development
Frontiers in Immunology·2023· 25 citedOpen Access
Multi-omic analyses in immune cell development with lessons learned from T cell development
Frontiers in Cell and Developmental Biology·2023· 6 citedOpen Access
Single-cell immune profiling reveals thymus-seeding populations, T cell commitment, and multilineage development in the human thymus
Science Immunology·2022· 62 citedOpen Access
IL3 Has a Detrimental Effect on Hematopoietic Stem Cell Self-Renewal in Transplantation Settings
International Journal of Molecular Sciences·2022· 17 citedOpen Access
Axin2/Conductin Is Required for Normal Haematopoiesis and T Lymphopoiesis
Cells·2022· 4 citedOpen Access
Single-cell immune profiling reveals novel thymus-seeding populations, T cell commitment, and multi-lineage development in the human thymus
2022· 4 citedOpen Access
Stem Cell-Based Disease Models for Inborn Errors of Immunity
Cells·2021· 1 citedOpen Access
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19
Nature Immunology·2021· 125 citedOpen Access
Forced degradation of cell-based medicinal products guided by flow imaging microscopy: Explorative studies with Jurkat cells
European Journal of Pharmaceutics and Biopharmaceutics·2021· 11 citedOpen Access
Combining Mobilizing Agents with Busulfan to Reduce Chemotherapy-Based Conditioning for Hematopoietic Stem Cell Transplantation
Cells·2021· 20 citedOpen Access
Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?
Frontiers in Cell and Developmental Biology·2021· 148 citedOpen Access
A Novel Branched DNA-Based Flowcytometric Method for Single-Cell Characterization of Gene Therapy Products and Expression of Therapeutic Genes
Frontiers in Immunology·2021· 8 citedOpen Access
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Frequent Co-authors

Frank J. T. Staal(47), Jacques J. M. van Dongen(13), Martijn H. Brugman(12), Laura García-Pérez(10), Dick de Ridder(8), Adrian J. Thrasher(8), Kirsten Canté-Barrett(7), Arjan C. Lankester(7), Anna‐Sophia Wiekmeijer(6), Miranda R.M. Baert(6), Gerard Wagemaker(6), Martijn Cordes(6), Steven J. Howe(5), Anton W. Langerak(5), Robbert G. M. Bredius(5), Marc R. Mansour(4), H. Bobby Gaspar(4), Monique M.A. Verstegen(4), Jules P.P. Meijerink(4), Floor Weerkamp(4)