Frank J. T. Staal

Leiden University Medical Center — Netherlands

Medicine · Health Sciences

70h-index18.1kcitations299works3.12yr avg
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Research Topics

CAR-T cell therapy research(48), Virus-based gene therapy research(44), Wnt/β-catenin signaling in development and cancer(41), Immune Cell Function and Interaction(41), Cancer-related gene regulation(39)

Publications296 total

Interleukin-6 restricts pre-thymic T cell lineage commitment of progenitors driving loss of SIV control
2026Open Access
RAG1 lentiviral gene therapy restores T-cell development of RAG1-SCID patient cells in artificial thymic organoids
Blood Advances·2025· 1 citedOpen Access
Ex vivo-generated lymphoid progenitors encompass both T cell and innate lymphoid cell fates
Frontiers in Immunology·2025Open Access
Navigating disruption in the PID landscape: embracing opportunities and anticipating threats in the next ten years
Frontiers in Immunology·2025Open Access
Safety and efficacy of gene therapy for RAG1-deficient SCID
Molecular Therapy·2025· 1 cited
The epigenetic reader MORC3 is required for T cell development in the thymus
2025Open Access
European Society for Immunodeficiencies guidelines for the management of patients with congenital athymia
Journal of Allergy and Clinical Immunology·2024· 17 citedOpen Access
Gene therapy strategies for RAG1 deficiency: Challenges and breakthroughs
Immunology Letters·2024· 6 citedOpen Access
Restoration of T and B Cell Differentiation after RAG1 Gene Transfer in Human RAG1 Defective Hematopoietic Stem Cells
Biomedicines·2024· 4 citedOpen Access
Utilizing epigenetic regulators to improve HSC-based lentiviral gene therapy
Blood Advances·2024· 4 citedOpen Access
Longitudinal soluble marker profiles reveal strong association between cytokine storms resulting from macrophage activation and disease severity in COVID-19 disease
Scientific Reports·2024· 4 citedOpen Access
Newborn Screening Today and Tomorrow: A Brief Report from the International Primary Immunodeficiencies Congress
International Journal of Neonatal Screening·2024· 3 citedOpen Access
Driving CAR-T cells toward solid lung tumors
Molecular Therapy Oncology·2024Open Access
Lentiviral Gene Therapy for Mucopolysaccharidosis II with Tagged Iduronate 2-Sulfatase Prevents Life-Threatening Pathology in Peripheral Tissues But Fails to Correct Cartilage
Human Gene Therapy·2023· 3 citedOpen Access
Independent validation of CT radiomics models in colorectal liver metastases: predicting local tumour progression after ablation
European Radiology·2023· 7 citedOpen Access
Partial correction of immunodeficiency by lentiviral vector gene therapy in mouse models carrying Rag1 hypomorphic mutations
Frontiers in Immunology·2023· 4 citedOpen Access
Single-Cell-Multiomics Demonstrates Molecular Efficacy of a Clinical Lentiviral Vector for Gene Therapy of RPS19-Deficient Diamond-Blackfan Anemia
Blood·2023· 1 cited
Tagged IDS causes efficient and engraftment-independent prevention of brain pathology during lentiviral gene therapy for Mucopolysaccharidosis type II
Molecular Therapy — Methods & Clinical Development·2023· 6 citedOpen Access
Advances in gene therapy for inborn errors of immunity
Current Opinion in Allergy and Clinical Immunology·2023· 22 citedOpen Access
The recombinase activating genes: architects of immune diversity during lymphocyte development
Frontiers in Immunology·2023· 25 citedOpen Access
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Frequent Co-authors

Jacques J. M. van Dongen(13), Karin Pike‐Overzet(12), Martijn H. Brugman(8), Dick de Ridder(8), Edwin F. E. de Haas(8), Miranda R.M. Baert(8), Mario Roederer(7), L A Herzenberg(7), Leonore A. Herzenberg(7), Floor Weerkamp(7), Gerard Wagemaker(6), Stephen W. Ela(5), Leonard A. Herzenberg(5), Manfred Schmidt(4), Christof von Kalle(4), Adrian J. Thrasher(4), Tiago C. Luís(4), Brigitta A. E. Naber(4), Steven J. Howe(3), Kerstin Schwarzwaelder(3)