Axel Schambach

Boston Children's Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

79h-index21.7kcitations577works3.42yr avg
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Research Topics

Virus-based gene therapy research(214), CRISPR and Genetic Engineering(180), CAR-T cell therapy research(140), RNA Interference and Gene Delivery(102), Pluripotent Stem Cells Research(65)

Publications577 total

Functional differences between CLL‐ and ALL‐derived CAR T cells in a 3D tumor microenvironment highlight CXCR4 and IL‐10 as potential modulatory targets
HemaSphere·2025Open Access
Improved Antitumor Activity of Interleukin-12-Secreting Chimeric Antigen Receptor T Cells Targeting CD176 across Different Carcinomas
Transfusion Medicine and Hemotherapy·2025Open Access
Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonality
2025Open Access
Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1
Obstetrical & Gynecological Survey·2025
<scp>RAD50</scp> missense variants differentially affect the <scp>DNA</scp> damage response and mitotic progression
FEBS Letters·2025Open Access
Combination of targeted pharmacotherapy and immunotherapy with anti‐CD19 CAR NK cells in acute lymphoblastic leukemia
HemaSphere·2025· 2 citedOpen Access
Base edited “universal” donor CAR T-cell strategies for acute myeloid leukaemia
Leukemia·2025· 2 citedOpen Access
<scp>LMP2A</scp> ‐Targeting <scp>CAR</scp> ‐T Cells Equipped With Inducible <scp>IL</scp> ‐18 to Address <scp>EBV</scp> ‐Associated Malignancies
HLA·2025Open Access
Antiviral siRNA multiplex treatment reduces HPIV3 infection and modulates inflammation in human precision-cut lung slices.
2025
Anti-FAP CAR-NK cells as a novel targeted therapy against cervical cancer and cancer-associated fibroblasts
OncoImmunology·2025· 2 citedOpen Access
Author response for "&lt;scp&gt;RAD50&lt;/scp&gt; missense variants differentially affect the &lt;scp&gt;DNA&lt;/scp&gt; damage response and mitotic progression"
2025
IFN‐γ‐Induced CD317 Tethers Extracellular Vesicles to Mesenchymal Stromal Cells Interfering With Immune Modulation
Journal of Extracellular Vesicles·2025· 1 citedOpen Access
Somatic hypermutation shapes the viral escape profile of SARS-CoV-2 neutralising antibodies
EBioMedicine·2025· 1 citedOpen Access
Inhaled Palmitoyl-conjugated Antiviral siRNA Reduces Human Parainfluenza Viral Infection In Vivo
American Journal of Respiratory and Critical Care Medicine·2025
Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1
New England Journal of Medicine·2025· 8 cited
Advanced Test Models for Delivery and Therapeutic Window of Novel Inhalable RNA Therapies
American Journal of Respiratory and Critical Care Medicine·2025
Septin7 is essential in early hematopoiesis, but redundant at later stages
2025Open Access
Meta-Analysis and Optimization of the <i>In Vitro</i> Immortalization Assay for Safety Assessment of Retroviral Vectors in Gene Therapy
Human Gene Therapy·2025· 3 citedOpen Access
Dual Topoisomerase Inhibitor Is Highly Potent and Improves Antitumor Response to Radiotherapy in Cervical Carcinoma
International Journal of Molecular Sciences·2025Open Access
Safety and efficacy of gene therapy for RAG1-deficient SCID
Molecular Therapy·2025· 1 cited
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Frequent Co-authors

Christopher Baum(9), Tobias Maetzig(8), Christopher Baum(7), Daniela Zychlinski(6), Adrian J. Thrasher(6), Melanie Galla(6), Ute Modlich(5), Jens Bohne(5), Julia Skokowa(4), David A. Williams(4), Tobias Cantz(4), Gunnar Cario(3), Martin Stanulla(3), Karl Welte(3), Adrian Schwarzer(3), Manfred Schmidt(3), Christoph Klein(3), H. Bobby Gaspar(3), Robert Zweigerdt(3), Jan‐Henning Klusmann(3)