John Manis

Brigham and Women's Hospital — United States

Immunology and Microbiology · Life Sciences

51h-index13.6kcitations144works2.12yr avg
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Research Topics

T-cell and B-cell Immunology(42), Immune Cell Function and Interaction(34), DNA Repair Mechanisms(33), CRISPR and Genetic Engineering(23), Hemoglobinopathies and Related Disorders(14)

Publications144 total

Challenges and limitations of mobilization and stem cell collection for gene therapy of sickle cell disease
Blood Advances·2025Open Access
A Web‐Based Calculator for Hematopoietic Progenitor Cell Collections: App Development and Retrospective Assessment
Journal of Clinical Apheresis·2025
Efficient, potent, and specific near-universal base and prime editing for ELANE-mutant severe congenital neutropenia
Blood·2025
Apheresis blood processing with heparin improves stem cell collection outcomes for sickle cell gene therapy
Blood·2025
Efficacy of motixafortide plus G-CSF versus plerixafor plus G-CSF for stem cell mobilization and collection in multiple myeloma: A single-center comparative analysis and interim Results from a prospective study in poor mobilizers
Blood·2025Open Access
Improved hematopoietic stem cell mobilization for gene therapy using single agent motixafortide in sickle cell disease
Blood·2025Open Access
In Vivo correction of the sickle cell disease mutation in hematopoietic stem cells using RNA gene writers
Blood·2025Open Access
Highly efficient collection and manufacture of autologous HSC gene therapy cell product for patients with sickle cell disease using a lentiviral vector containing a shmir targeting BCL11a
Blood·2025
Efficient prime editing of human hematopoietic stem cells corrects the recurrent SBDS C.258+2T>C mutation and recovers engraftment potential in shwachman-diamond syndrome
Blood·2025
Long-term follow-up of the first in human post-transcriptional genetic silencing of BCL11A in sickle cell disease in a phase 1 pilot and feasibility trial
Blood·2025
Analyzing long-read CRISPR experiments with CRISPRLungo
2025Open Access
Discovery of A Small Molecule non-IMiD Degrader of ZBTB7A for the Treatment of β-hemoglobinopathies
2025· 1 citedOpen Access
The Red Blood Cell-Improving Transfusions for Chronically Transfused Recipients (RBC-IMPACT) study: protocol description of an international multi-site observational clinical study.
PubMed·2025Open Access
Bone Marrow Adipokine Mediates Hematopoietic Regeneration and Stem Cell Fitness
2025Open Access
Comparative Analysis of Motixafortide versus Plerixafor for Stem Cell Mobilization and Collection in Multiple Myeloma: A Single Center Real-World Experience
Clinical Lymphoma Myeloma & Leukemia·2025
Ocular Oncologists and Ophthalmic Pathologists in Academic Ophthalmology: A Descriptive Analysis of the Current Workforce in the United States
American Journal of Ophthalmology·2025
Extracorporeal Photopheresis After Lung Transplantation: A Single Pediatric Center Experience
The Journal of Heart and Lung Transplantation·2025Open Access
A progranulin variant causing childhood interstitial lung disease responsive to anti-TNF-α biologic therapy
Med·2025Open Access
Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease
Nature Communications·2025· 7 citedOpen Access
In vivo HSC Gene Therapy Using BaEVRLess-Pseudotyped Alpha-Retroviral and Lentiviral Vectors
SSRN Electronic Journal·2025Open Access
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Frequent Co-authors

Frederick W. Alt(32), Luigi D. Notarangelo(8), Sonia Franco(6), David O. Ferguson(6), JoAnn Sekiguchi(5), Jayanta Chaudhuri(5), Catherine T. Yan(5), Klaus Rajewsky(5), Monica Gostissa(4), Michael Murphy(4), Ali A. Zarrin(4), Erica B. Esrick(4), David A. Williams(4), Chengming Zhu(4), Laurie A. Davidson(4), Raif S. Geha(4), Silvia Giliani(4), Yansong Gu(3), Karen M. Frank(3), Cristian Boboilă(3)