Catherine T. Yan

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index2.9kcitations31works0.02yr avg
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Research Topics

DNA Repair Mechanisms(17), Immune Cell Function and Interaction(7), T-cell and B-cell Immunology(6), Cytomegalovirus and herpesvirus research(6), Acute Lymphoblastic Leukemia research(4)

Publications31 total

Regulation of DNA repair in the absence of classical non-homologous end joining
DNA repair·2018· 23 cited
Correction: Corrigendum: Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival
Nature Communications·2017· 118 citedOpen Access
Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival
Nature Communications·2017· 26 citedOpen Access
The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining
The Journal of Immunology·2015· 8 citedOpen Access
Lig4 Is Essential for Maintaining HSC Homeostasis
Blood·2014· 1 cited
Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity
Blood·2014· 15 citedOpen Access
Lig4 modulates p53-p21 checkpoints and inhibits A-EJ during end-joining repair phase of IgH class switching (LYM6P.770)
The Journal of Immunology·2014
The essential role of Ligase 4 in hematopoietic stem cell homeostasis (HEM2P.257)
The Journal of Immunology·2014
The Essential Role of DNA Repair in Hematopoietic Stem Cell Homeostasis and Disease.
Blood·2012
Integrated RNA-Seq-Mirnome Analysis Reveal Interplay of Multiple Cancer Signaling Pathways Involved in B Lymphomagenesis
Blood·2012
Lig4 R278H Mutation Impacts on LT-HSC Functions, Cancer Development and Aging
Blood·2011
Conditional C-Myc Inactivation Impacts on Chromosomal Translocation Mechanisms and B Lymphomagenesis
Blood·2011
Mismatch Repair Proteins MSH2, MLH1, and EXO1 Are Important for Class-Switch Recombination Events Occurring in B Cells That Lack Nonhomologous End Joining
The Journal of Immunology·2011· 41 citedOpen Access
Hypomorphic Lig4 Impacts on Igh Class Switching and Translocations.
Blood·2010
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
The Journal of Cell Biology·2010· 5 cited
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
The Journal of Experimental Medicine·2010· 192 citedOpen Access
Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome
Proceedings of the National Academy of Sciences·2010· 48 citedOpen Access
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70
Proceedings of the National Academy of Sciences·2010· 195 citedOpen Access
Long-range oncogenic activation of Igh–c-myc translocations by the Igh 3′ regulatory region
Nature·2009· 90 citedOpen Access
Mechanisms promoting translocations in editing and switching peripheral B cells
Nature·2009· 124 citedOpen Access
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Frequent Co-authors

Frederick W. Alt(17), Jing Wang(7), John Manis(6), Robert S. Welner(6), Daniel G. Tenen(5), Cristian Boboilă(4), Ali A. Zarrin(4), Monica Gostissa(4), Duane R. Wesemann(4), Michel C. Nussenzweig(4), Youn‐Jung Kang(4), Barbara B. Balter(4), Logan Troppito(4), Sonia Franco(3), Thomas R. Hickernell(3), Michael Murphy(3), Klaus Rajewsky(3), JoAnn Sekiguchi(3), Abhishek Datta(3), Mila Janković(3)