Andrew F. Wilderspin

University College London — United Kingdom

Medicine · Health Sciences

17h-index1.5kcitations43works0.02yr avg
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Research Topics

HIV/AIDS drug development and treatment(10), HIV Research and Treatment(8), Cytokine Signaling Pathways and Interactions(6), Monoclonal and Polyclonal Antibodies Research(5), RNA Interference and Gene Delivery(4)

Publications43 total

A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3)
Oncotarget·2018· 14 citedOpen Access
Protocol for a Steady-State FRET Assay in Cancer Chemoprevention
Methods in molecular biology·2015
Development of a steady‐state FRET‐based assay to identify inhibitors of the Keap1‐Nrf2 protein–protein interaction
Protein Science·2013· 32 citedOpen Access
Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry
Bioorganic & Medicinal Chemistry Letters·2013· 50 cited
Observation of unphosphorylated STAT3 core protein binding to target <i>ds</i>DNA by PEMSA and X‐ray crystallography
FEBS Letters·2013· 73 citedOpen Access
Abstract 1382: Use of polarized light spectroscopy (CD) to study STAT3 folding and STAT3:ligand interactions
Cancer Research·2011
Abstract 279: Use of GFP-STAT3βtc for EMSA analysis of protein-protein and protein-DNA interactions in tumorigenic signalling pathways
Cancer Research·2011
Use of polarized light spectroscopy (CD) to study STAT3 folding and STAT3:ligand interactions
Cancer Research·2011
A novel small-molecule inhibitor of IL-6 signalling
Bioorganic & Medicinal Chemistry Letters·2010· 24 citedOpen Access
Abstract 5454: Novel STAT3:STAT3 small-molecule inhibitors as potential anticancer agents
Cancer Research·2010
Solid-Phase Synthesis of Chlorofusin Analogues
The Journal of Organic Chemistry·2007· 21 cited
Protein transduction by lipidic peptide dendrimers
Journal of Pharmaceutical Sciences·2006· 28 cited
Versatile Peptide Dendrimers for Nucleic Acid Delivery
Journal of Pharmaceutical Sciences·2004· 64 cited
A PROTEOMIC APPROACH TO THE IDENTIFICATION OF CYTOCHROME P450 ISOFORMS IN MALE AND FEMALE RAT LIVER BY NANOSCALE LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION-TANDEM MASS SPECTROMETRY
Drug Metabolism and Disposition·2004· 32 cited
cAMP-SPECIFIC PHOSPHODIESTERASE IVAI EXPRESSION IN A MAMMALIAN SYSTEM
Biochemical Society Transactions·2000
Identification of an inhibitory Zn<sup>2+</sup> binding site on the human glycine receptor α1 subunit
The Journal of Physiology·1999· 97 citedOpen Access
Investigation of transfection & cell viability using high concentrations of lipidic dendrimeric lysine.
1999
Novel cationic lipidic peptide dendrimer vectors in vitro gene delivery
UCL Discovery (University College London)·1999· 30 cited
Autocatalytic processing of mutant SIV-PR polyproteins
Biochemical Society Transactions·1998
97 Characterisation of drug resistant retroviral proteinase mutants
Biochemical Society Transactions·1997· 1 cited
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Frequent Co-authors

Giovanna Zinzalla(7), David E. Thurston(7), Jonathan Palmer(5), Khondaker Miraz Rahman(5), Edwin Nkansah(4), István Tóth(4), Samantha Essex(4), Richard J. Sugrue(4), Duncan J. H. Gaskin(4), Risto Lapatto(3), Andrew M. Hemmings(3), Peter J. Whittle(3), Dennis E. Danley(3), Peter Hobart(3), C. James(3), Tam T. T. Bui(3), Stephen Neidle(3), Henry K. Bayele(3), Thiagarajan Sakthivel(3), Dyeison Antonow(3)