Kazuko Shibuya

University of Tsukuba — Japan

Immunology and Microbiology · Life Sciences

36h-index6.4kcitations101works1.92yr avg
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Research Topics

Immune Cell Function and Interaction(70), T-cell and B-cell Immunology(52), Immunotherapy and Immune Responses(22), Immune cells in cancer(18), Immune Response and Inflammation(17)

Publications101 total

A co-stimulatory signal via the coinhibitory TIGIT
Nature Immunology·2025
The Development of Monoclonal Antibodies Specific to the Soluble Form of CD155 in the Human Peripheral Blood
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·2025· 1 cited
Tn antigen suppresses lipopolysaccharide-induced dermatitis via Clec10a
Biochemical and Biophysical Research Communications·2025Open Access
Inhibitory immunoreceptors CD300a and CD300lf cooperate to regulate mast cell activation
The Journal of Immunology·2025· 3 citedOpen Access
CD96 enhances the anti-viral activity of natural killer cells by promoting Ly49H-mediated activation during mouse cytomegalovirus infection
Molecular Immunology·2025· 3 cited
A Humanized Monoclonal Antibody Against CD300A Ameliorates Acute Ischemic Stroke in Humanized Mice
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·2025
Clec12b Alleviates Mite‐Induced Dermatitis by Regulating <scp>P2RX7</scp>‐Mediated Mast Cell Activation in Mice
Allergy·2024Open Access
THEMIS2 Impairs Antitumor Activity of NK Cells by Suppressing Activating NK Receptor Signaling
The Journal of Immunology·2024· 5 cited
Essential role of CD155 glycosylation in functional binding to DNAM-1 on natural killer cells
International Immunology·2024· 5 citedOpen Access
Development of Monoclonal Antibodies Specific to Either CD300A <sup>R111</sup> or CD300A <sup>Q111</sup> or Both
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·2023· 2 cited
DNAM-1 Immunoreceptor Protects Mice from Concanavalin A–Induced Acute Liver Injury by Reducing Neutrophil Infiltration
The Journal of Immunology·2023· 6 cited
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy
The Journal of Experimental Medicine·2023· 14 citedOpen Access
CD96 Blockade Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis via Suppression of IL-17A Production by Dermal γδ T Cells
The Journal of Immunology·2022· 5 citedOpen Access
G307S DNAM-1 Mutation Exacerbates Autoimmune Encephalomyelitis via Enhancing CD4+ T Cell Activation
The Journal of Immunology·2022· 4 citedOpen Access
<scp>CD155</scp> mutation (<scp>Ala67Thr</scp>) increases the binding affinity for and the signaling via an inhibitory immunoreceptor <scp>TIGIT</scp>
Cancer Science·2022· 9 citedOpen Access
DNAM-1 versus TIGIT: competitive roles in tumor immunity and inflammatory responses
International Immunology·2021· 54 citedOpen Access
DNAM-1 promotes inflammation-driven tumor development via enhancing IFN-γ production
International Immunology·2021· 3 cited
DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions
Proceedings of the National Academy of Sciences·2021· 46 citedOpen Access
Suppression of Th1 and Th17 Proinflammatory Cytokines and Upregulation of FOXP3 Expression by a Humanized Anti-DNAM-1 Monoclonal Antibody
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·2021· 5 cited
Tumor-derived soluble CD155 inhibits DNAM-1–mediated antitumor activity of natural killer cells
The Journal of Experimental Medicine·2020· 95 citedOpen Access
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Frequent Co-authors

Akira Shibuya(43), Satoko Tahara‐Hanaoka(22), Shin‐ichiro Honda(16), Hiromitsu Nakauchi(7), Chigusa Nakahashi-Oda(7), Hirayasu Kai(6), Anne O’Garra(5), Akiko Iguchi‐Manaka(5), Akitomo Miyamoto(5), Shin-ichiro Honda(5), Naoya Totsuka(5), Kenneth M. Murphy(4), Yumi Yamashita(4), Kai Shibata(4), Hitoshi Kikutani(4), Yumi Yamashita-Kanemaru(4), Satoru Takahashi(4), Akio Kôyama(4), Douglas S. Robinson(3), Francesca Zonin(3)