James Longden

Mott MacDonald (United Kingdom) — United Kingdom

Computer Science · Physical Sciences

11h-index480citations31works0.72yr avg
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Research Topics

Computational Drug Discovery Methods(8), Bioinformatics and Genomic Networks(6), Amyotrophic Lateral Sclerosis Research(5), Pluripotent Stem Cells Research(4), Cell Image Analysis Techniques(4)

Publications31 total

Exploring Machine Learning Models to Uncover Pathways in ALS Pathogenesis Using Immunohistochemical Features
2025Open Access
Systematic Living Evidence for Clinical Trials (SyLECT): a data-driven framework for drug selection in clinical trials in motor neuron disease
2025Open Access
Machine learning identifies routine blood tests as accurate predictive measures of pollution-dependent poor cognitive function
2025· 2 citedOpen Access
Cell-autonomous immune dysfunction driven by disrupted autophagy in <i>C9orf72</i> -ALS iPSC-derived microglia contributes to neurodegeneration
Science Advances·2023· 45 citedOpen Access
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in <scp> <i>C9orf72</i> ‐ALS </scp>
The Journal of Pathology·2022· 19 citedOpen Access
Cell-autonomous immune dysfunction driven by disrupted autophagy in <i>C9orf72</i> -ALS iPSC-derived microglia contributes to neurodegeneration
2022· 2 citedOpen Access
Drug Targeting
Elsevier eBooks·2022
Random forest modelling of neuropathological features identifies microglial activation as an accurate pathological classifier of C9orf72-related amyotrophic lateral sclerosis
2021· 1 citedOpen Access
Deep Hidden Physics Modeling of Cell Signaling Networks
Current Genomics·2021· 1 citedOpen Access
Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients
SLAS DISCOVERY·2021· 8 citedOpen Access
NODAL/TGFβ signalling mediates the self-sustained stemness induced by <i>PIK3CAH1047R</i> homozygosity in pluripotent stem cells
Disease Models & Mechanisms·2021· 10 citedOpen Access
Deep neural networks identify signaling mechanisms of ErbB-family drug resistance from a continuous cell morphology space
Cell Reports·2021· 14 citedOpen Access
Author Reply to Peer Reviews of NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells
2020
NODAL/TGFβ signalling mediates the self-sustained stemness induced by <i>PIK3CA</i> <sup> <i>H1047R</i> </sup> homozygosity in pluripotent stem cells
2019· 1 citedOpen Access
High-dose oncogenic PIK3CA drives constitutive cellular stemness through self-sustained TGFβ pathway activation
2019· 1 cited
Global view of the RAF-MEK-ERK module and its immediate downstream effectors
Scientific Reports·2019· 13 citedOpen Access
Probability-based detection of phosphoproteomic uncertainty reveals rare signaling events driven by oncogenic kinase gene fusion
2019· 5 citedOpen Access
Bowhead: Bayesian modelling of cell velocity during concerted cell migration
PLoS Computational Biology·2018· 3 citedOpen Access
Deep Neural Networks Identify Signaling Mechanisms of ErbB-Family Drug Resistance From a Continuous Cell Morphology State Space
SSRN Electronic Journal·2018Open Access
Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments
Cell Reports·2017· 24 citedOpen Access
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Frequent Co-authors

Rune Linding(13), Xavier Robin(9), Vicky M. Avery(6), Neil O. Carragher(6), Jesper Ferkinghoff‐Borg(5), Peter C. Healy(5), Siddharthan Chandran(5), Rohan A. Davis(4), Jenna M. Gregory(4), Mathias Engel(4), Ralitsa R. Madsen(4), Rachel Knox(4), Franziska Völlmy(4), Kenneth G. MacLeod(4), Larissa S. Moniz(4), Bart Vanhaesebroeck(4), Robert K. Semple(4), Pau Creixell(3), Craig D. Simpson(3), Karina McDade(3)