Bart Vanhaesebroeck

Biochemistry, Genetics and Molecular Biology · Life Sciences

78h-index28.8kcitations332works3.22yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(118), Protein Kinase Regulation and GTPase Signaling(39), Chronic Lymphocytic Leukemia Research(30), Immune Cell Function and Interaction(22), T-cell and B-cell Immunology(20)

Publications332 total

Optimising anti-PI3Kd and anti-LAG-3 immunotherapy dosing regimens in a mouse model of triple negative breast cancer improves outcome by removing treatment-related adverse events
New Trends in Mathematical Science·2026Open Access
Figure 1 from HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models
2025Open Access
Figure 3 from HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models
2025Open Access
Figure 2 from HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models
2025Open Access
Figure 6 from HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models
2025Open Access
Figure 5 from HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models
2025Open Access
Figure 4 from HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models
2025Open Access
Novel role for PI3Kβ in placental function through regulation of system A amino acid transporter expression, associated with embryonic lethality
Cellular and Molecular Life Sciences·2025Open Access
Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome
Disease Models & Mechanisms·2025· 1 citedOpen Access
Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
A mouse model of PTEN Hamartoma Tumour Syndrome reveals that loss of the nuclear function of PTEN drives macrocephaly, lymphoid overgrowth, and late-onset cancer
2025Open Access
mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node
Orphanet Journal of Rare Diseases·2025· 5 citedOpen Access
PI3Kδ Bridges Microbial Surveillance with Antigen Presentation to Reinforce Intestinal Immunity
2025Open Access
Context-dependent response of endothelial cells to <i>PIK3CA</i> mutation
2025· 4 citedOpen Access
Oncogenic PIK3CA corrupts growth factor signaling specificity
Molecular Systems Biology·2024· 10 citedOpen Access
Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development
Frontiers in Immunology·2024· 5 citedOpen Access
The amino acid transporter SLC7A5 drives progression of PI3K-mutant intestinal cancer models and enhances response to MAPK-targeted therapy
2024Open Access
A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease
Nature Communications·2024· 11 citedOpen Access
Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus
Nature Genetics·2024· 18 citedOpen Access
An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration
Developmental Cell·2024· 12 citedOpen Access
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Frequent Co-authors

Klaus Okkenhaug(16), Wayne Pearce(9), Michael D. Waterfield(8), Antonio Bilancio(7), Julie Guillermet‐Guibert(5), Mariona Graupera(4), Stephen Meek(4), Khaled Ali(4), Lazaros C. Foukas(4), Benoît Bilanges(3), Len Stephens(3), Phillip T. Hawkins(3), Sara Sancho(3), Emma Peskett(3), Ashreena Salpekar(3), Marketa Zvelebil(3), Stefano Volinia(3), Andrew J. H. Smith(3), Barbara Geering(3), Faruk Ramadani(3)