Wayne Pearce

Cancer Research UK — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

29h-index5.0kcitations50works2.62yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(14), Immune Cell Function and Interaction(5), Metabolism, Diabetes, and Cancer(4), Renal and related cancers(4), T-cell and B-cell Immunology(3)

Publications50 total

Novel role for PI3Kβ in placental function through regulation of system A amino acid transporter expression, associated with embryonic lethality
Cellular and Molecular Life Sciences·2025Open Access
Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome
Disease Models & Mechanisms·2025· 1 citedOpen Access
Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
A mouse model of PTEN Hamartoma Tumour Syndrome reveals that loss of the nuclear function of PTEN drives macrocephaly, lymphoid overgrowth, and late-onset cancer
2025Open Access
A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease
Nature Communications·2024· 11 citedOpen Access
Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development
The Journal of Pathology·2022· 17 citedOpen Access
Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy
Nature Communications·2021· 61 citedOpen Access
Abstract B22: Investigation of PTEN genotype-phenotype correlations in the PTEN hamartoma tumor syndrome (PHTS) using in vitro and in vivo approaches
Molecular Cancer Research·2020· 1 cited
Oncogenic <i>PIK3CA</i> promotes cellular stemness in an allele dose-dependent manner
Proceedings of the National Academy of Sciences·2019· 62 citedOpen Access
Oncogenic <i>PIK3CA</i> promotes cellular stemness in an allele dose-dependent manner
2018· 3 citedOpen Access
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
Nature Communications·2017· 77 citedOpen Access
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
Nature Communications·2017· 74 citedOpen Access
Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice
Diabetologia·2016· 49 citedOpen Access
Erratum: Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
Nature·2016· 5 cited
Somatic activating mutations in <i>Pik3ca</i> cause sporadic venous malformations in mice and humans
Science Translational Medicine·2016· 182 citedOpen Access
Reduced Akt and increased RhoA/PTEN signaling in DRG neurons with inactive p110δ.
Figshare·2015Open Access
Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity
Cell Reports·2015· 69 citedOpen Access
Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells
PLoS Genetics·2015· 50 citedOpen Access
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
Nature·2014· 529 citedOpen Access
Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
The Journal of Cell Biology·2013
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Frequent Co-authors

Bart Vanhaesebroeck(38), Clemens Sorg(15), Cheryl L. Scudamore(11), Sergij Goerdt(10), Constantin E. Orfanos(10), Vitam Kodelja(10), G. Schmitz(10), Jochen Klucken(10), E. Orsó(10), Hubert Kolb(10), Hans‐Dieter Volk(10), Klaus Okkenhaug(9), Khaled Ali(8), Mariona Graupera(8), Andrew J. Rees(8), Manfred Kauer(8), Anne Devine(7), Julie Guillermet‐Guibert(6), Antonio Bilancio(5), Lori S. Friedman(5)