Phillip T. Hawkins

Babraham Institute — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

75h-index23.9kcitations256works1.42yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(91), PI3K/AKT/mTOR signaling in cancer(68), Cellular transport and secretion(46), Neutrophil, Myeloperoxidase and Oxidative Mechanisms(38), Pancreatic function and diabetes(24)

Publications255 total

Abstract 4365683: Mapping the Myocardial Amyloid Burden in Transthyretin Cardiomyopathy: A Large-Scale Study Using Cardiac Magnetic Resonance and Extracellular Volume in 1,400 Patients
Circulation·2025
P-Rex1 controls phagocytosis and the killing of bacteria by murine neutrophils independently of its catalytic activity
Frontiers in Immunology·2025· 1 citedOpen Access
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis
Nature Chemical Biology·2025· 1 cited
FGF-induced phospholipase Cγ signaling regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism
Cell Reports·2025· 1 citedOpen Access
The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types
Nature Genetics·2025· 8 citedOpen Access
Somatic NLRP3 mosaicism in patients with “mutation-negative” CAPS: insights from a single centre UK cohort
Frontiers in Pediatrics·2025· 2 citedOpen Access
Phosphoinositide acyl chain diversity: comparative analysis across species and mouse tissues
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2025Open Access
Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling
PLoS Biology·2025· 1 citedOpen Access
Abstract 4144740: Characteristics and Natural History of Early ATTR Cardiac Amyloid Infiltration
Circulation·2024
Co-designing a nutritional navigation guide for people with psoriasis: a user-centred design approach
Proceedings of The Nutrition Society·2024Open Access
CDS2 expression regulates <i>de novo</i> phosphatidic acid synthesis
Biochemical Journal·2024· 4 citedOpen Access
The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signaling
Molecular Biology of the Cell·2024· 2 citedOpen Access
Phospholipase Cγ regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism
2024Open Access
p110α-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD
2024Open Access
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
Molecular Cell·2023· 12 citedOpen Access
Genome-wide CRISPR-Cas9 screening to identify <i>CDS2 </i>as an essential gene in uveal melanoma.
Journal of Clinical Oncology·2023· 1 cited
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Nature·2023· 138 citedOpen Access
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
2023Open Access
Figure S3 from SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance
2023Open Access
Figure S5 from SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance
2023Open Access
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Frequent Co-authors

Len Stephens(45), Karen E. Anderson(16), Trevor Jackson(10), Keith Davidson(8), Chris D. Ellson(8), John Coadwell(7), Gail Ferguson(7), Roger Williams(6), Frank T. Cooke(6), A. Eguinoa(6), Olga Perišić(5), Hediye Erdjument‐Bromage(5), Paul Tempst(5), Heidi C. E. Welch(5), Andrew B. Holmes(4), Jonathan Clark(4), Edwin R. Chilvers(4), Klaus Okkenhaug(4), W. John Coadwell(4), Simon Andrews(4)