Hediye Erdjument‐Bromage

Neurosciences Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

134h-index85.4kcitations367works3.02yr avg
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Research Topics

Genomics and Chromatin Dynamics(52), Epigenetics and DNA Methylation(49), Ubiquitin and proteasome pathways(44), Cancer-related gene regulation(36), RNA Research and Splicing(35)

Publications367 total

Palaeometabolomes yield biological and ecological profiles at early human sites
Nature·2025Open Access
The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
Science·2025· 1 cited
Mapping Dysfunctional Protein-Protein Interactions in Disease
Journal of Visualized Experiments·2025Open Access
Protocol for culture, purification, and target validation of a hybridoma-generated monoclonal antibody targeting Aβ truncated species
STAR Protocols·2025Open Access
Abstract Tu0079: Integrated microRNA and Proteomic Expression Profiling in Small Extracellular Vesicles derived from Diabetic Macrophages Identifies Novel MicroRNA Targets and Networks Associated with Diabetic Vascular Complications
Arteriosclerosis Thrombosis and Vascular Biology·2025
Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum
2025· 1 citedOpen Access
Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation
Nature Communications·2024· 22 citedOpen Access
Spns1 is an iron transporter essential for megalin-dependent endocytosis.
American Journal of Physiology-Renal Physiology·2024Open Access
Abstract 2033: Bone Marrow-Derived Macrophage Extracellular Vesicles From Diabetic Mice Suppress Angiogenic Properties In Endothelial Cells
Arteriosclerosis Thrombosis and Vascular Biology·2024
Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1
Cell Reports·2024· 2 citedOpen Access
Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
2024· 1 citedOpen Access
VLK drives extracellular phosphorylation of EphB2 to govern the EphB2-NMDAR interaction and injury-induced pain
2024· 4 citedOpen Access
The BAP1 nuclear deubiquitinase is involved in the nonhomologous end-joining pathway of double-strand DNA repair through interaction with DNA-PK
Oncogene·2024· 8 citedOpen Access
Proteomic profiling of interferon‐responsive reactive astrocytes in rodent and human
Glia·2023· 29 citedOpen Access
Cardiolipin prolongs the lifetimes of respiratory proteins in Drosophila flight muscle
Journal of Biological Chemistry·2023· 5 citedOpen Access
Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr <sup>682</sup> -phosphorylated APP βCTF
Science Advances·2023· 64 citedOpen Access
PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma
Cell Reports·2023· 13 citedOpen Access
Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
Nature Communications·2023· 40 citedOpen Access
SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex
Nucleic Acids Research·2023· 25 citedOpen Access
Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho GTPase signaling
Frontiers in Aging Neuroscience·2023· 16 citedOpen Access
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Frequent Co-authors

Paul Tempst(50), Yi Zhang(14), Danny Reinberg(8), Hengbin Wang(7), David M. Sabatini(4), C. David Allis(4), Kenichi Yamane(4), Do‐Hyung Kim(3), Dos D. Sarbassov(3), Siraj M. Ali(3), Robert Latek(3), Kenichi Nishioka(3), Sankar Ghosh(3), Zhenbang Chen(3), Pier Paolo Pandolfi(3), Len Stephens(3), Phillip T. Hawkins(3), Huck‐Hui Ng(3), Qin Feng(3), Jiemin Wong(3)