David M. Sabatini

Czech Academy of Sciences — Czech Republic

Biochemistry, Genetics and Molecular Biology · Life Sciences

148h-index153.2kcitations531works8.72yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(212), Protein Kinase Regulation and GTPase Signaling(59), CRISPR and Genetic Engineering(49), Cancer, Hypoxia, and Metabolism(41), Polyamine Metabolism and Applications(41)

Publications525 total

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2
Science·2025· 1 citedOpen Access
BoltzGen: Toward Universal Binder Design
2025· 10 citedOpen Access
Atlas of Lysosomal Aging Reveals a Molecular Clock of Storage Disorder-Associated Metabolites
2025Open Access
Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
2025· 2 citedOpen Access
Lysosomal reduced thiols are essential for mouse embryonic development
Proceedings of the National Academy of Sciences·2025· 2 citedOpen Access
Structural basis for the dynamic regulation of mTORC1 by amino acids
Nature·2025· 7 citedOpen Access
Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders
Science·2025· 5 cited
Author Correction: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance
UNC Libraries·2025Open Access
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST
Cell Metabolism·2025· 25 cited
Rhodoquinone carries electrons in the mammalian electron transport chain
Cell·2025· 16 citedOpen Access
SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation
Nature Communications·2025· 10 citedOpen Access
Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation
Nature·2025· 1 cited
Lysosomal reduced thiols are essential for mouse embryonic development
2024· 1 citedOpen Access
Technologies for Decoding Cancer Metabolism with Spatial Resolution
Cold Spring Harbor Perspectives in Medicine·2024· 3 cited
Rag–Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway
Proceedings of the National Academy of Sciences·2024· 18 citedOpen Access
Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST
2024· 5 citedOpen Access
An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway
Nature Communications·2024· 24 citedOpen Access
Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
eLife·2024· 25 citedOpen Access
Author response: Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
2023Open Access
An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway
2023· 4 citedOpen Access
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Frequent Co-authors

Carson C. Thoreen(7), Dos D. Sarbassov(6), David A. Guertin(6), Siraj M. Ali(6), Roberto Zoncu(6), Timothy R. Peterson(6), Liron Bar‐Peled(6), Timothy C. Wang(6), Kıvanç Birsoy(6), Yasemin Sancak(5), Seong A. Kang(5), Robert A. Saxton(4), Anne E. Carpenter(4), Hediye Erdjument‐Bromage(4), Paul Tempst(4), Shomit Sengupta(4), Peggy P. Hsu(4), Nathanael S. Gray(4), Lynne Chantranupong(4), Mathieu Laplante(3)