Robert A. Saxton

University of California, Berkeley — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index12.9kcitations28works21.52yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(15), Polyamine Metabolism and Applications(9), Ubiquitin and proteasome pathways(5), Cytokine Signaling Pathways and Interactions(4), Immune Response and Inflammation(3)

Publications28 total

Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans
The Journal of Experimental Medicine·2024· 32 citedOpen Access
Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling
Molecular Cell·2024· 11 citedOpen Access
Structural insights into the mechanism of leptin receptor activation
Nature Communications·2023· 61 citedOpen Access
Emerging principles of cytokine pharmacology and therapeutics
Nature Reviews Drug Discovery·2022· 192 citedOpen Access
Structure of the nutrient-sensing hub GATOR2
Nature·2022· 72 citedOpen Access
Cryo‐EM structure of the IL‐10 receptor complex provides a blueprint for ligand engineering
FEBS Journal·2021· 10 citedOpen Access
The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
Immunity·2021· 64 citedOpen Access
IL-22 Signaling Complex with IL-22R1 and IL-10Rbeta
2020
Mechanisms of amino acid sensing by the mTORC1 pathway
DSpace@MIT (Massachusetts Institute of Technology)·2018· 1 citedOpen Access
X-Ray Diffraction data from Human Sestrin2, pseudo-apo form, source of 5T0N structure
Harvard SBGrid·2017Open Access
X-Ray Diffraction data from Human CASTOR1, Arg-bound, source of 5I2C structure
Harvard SBGrid·2017Open Access
X-Ray Diffraction data from Human Sestrin2, Leucine-bound, source of 5DJ4 structure
Harvard SBGrid·2017Open Access
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
PMC·2017· 11 cited
mTOR Signaling in Growth, Metabolism, and Disease
Cell·2017· 2.0k citedOpen Access
mTOR Signaling in Growth, Metabolism, and Disease
Cell·2017· 7.2k citedOpen Access
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
DSpace@MIT (Massachusetts Institute of Technology)·2016Open Access
The apo-structure of the leucine sensor Sestrin2 is still elusive
Science Signaling·2016· 26 citedOpen Access
The apo-structure of the leucine sensor Sestrin2 is still elusive
DSpace@MIT (Massachusetts Institute of Technology)·2016Open Access
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
RePEc: Research Papers in Economics·2016
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
Nature·2016· 324 citedOpen Access
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Frequent Co-authors

David M. Sabatini(15), Lynne Chantranupong(10), Kevin E. Knockenhauer(8), Thomas Schwartz(8), Sonia M. Scaria(6), K. Christopher García(6), Rachel L. Wolfson(5), Kuang Shen(4), Timothy C. Wang(4), Steven P. Gygi(4), J. Wade Harper(3), Jason R. Cantor(2), Melanie P. Gygi(2), Gregory A. Wyant(2), Jose M. Orozco(2), Michael E. Pacold(2), Xin Gu(2), Lukas T. Henneberg(2), Leon Su(2), Nathanael A. Caveney(2)