Rachel L. Wolfson

Harvard University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index6.4kcitations36works2.02yr avg
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Research Topics

Polyamine Metabolism and Applications(11), PI3K/AKT/mTOR signaling in cancer(10), Cellular transport and secretion(6), Pain Mechanisms and Treatments(4), Gastrointestinal motility and disorders(4)

Publications36 total

Interoception: The enteric nervous system enters the chat
Current Biology·2026
Spinal sensory innervation of the intestine
Current Opinion in Neurobiology·2025· 4 citedOpen Access
DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon
Cell·2023· 82 citedOpen Access
DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon
2022· 11 citedOpen Access
Parallel ascending spinal pathways for affective touch and pain
Nature·2020· 260 citedOpen Access
Defining the Extrinsic Sensory Innervation of the Distal Gastrointestinal Tract
Digital Access to Scholarship at Harvard (DASH) (Harvard University)·2019Open Access
Clinical Impact of Tumor Mutational Burden in Neuroblastoma
JNCI Journal of the National Cancer Institute·2018· 57 citedOpen Access
A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility
DSpace@MIT (Massachusetts Institute of Technology)·2018Open Access
A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility
Neurobiology of Disease·2017· 105 citedOpen Access
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
Cell·2017· 451 citedOpen Access
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
2017
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway
Cell Metabolism·2017· 540 citedOpen Access
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway
DSpace@MIT (Massachusetts Institute of Technology)·2017Open Access
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
Nature·2017· 310 citedOpen Access
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
DSpace@MIT (Massachusetts Institute of Technology)·2017Open Access
Understanding the nutrient sensing branch upstream of mTORC1
DSpace@MIT (Massachusetts Institute of Technology)·2017
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
DSpace@MIT (Massachusetts Institute of Technology)·2016Open Access
Erratum: Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Nature Genetics·2016· 2 citedOpen Access
Sestrin2 is a leucine sensor for the mTORC1 pathway
PMC·2016· 1 cited
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
Science·2015· 434 citedOpen Access
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Frequent Co-authors

David M. Sabatini(22), Lynne Chantranupong(11), Kuang Shen(6), Gregory A. Wyant(6), Roberto Zoncu(6), Robert A. Saxton(5), Sonia M. Scaria(5), Alejo Efeyan(5), Monther Abu-Remaileh(4), Paul E. Wischmeyer(4), Madelyn Kahana(4), Timothy C. Wang(3), Liron Bar‐Peled(3), Seungwon Choi(3), David D. Ginty(3), Jason R. Cantor(2), Zhi-Yang Tsun(2), Molly Plovanich(2), Tony D. Jones(2), William C. Comb(2)