Roberto Zoncu

University of California, San Francisco — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

49h-index26.8kcitations121works3.82yr avg
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Research Topics

Cellular transport and secretion(47), Autophagy in Disease and Therapy(32), Calcium signaling and nucleotide metabolism(27), PI3K/AKT/mTOR signaling in cancer(21), Lysosomal Storage Disorders Research(9)

Publications121 total

Reprogramming of cholesterol sensing in epithelial cells supports pancreatic inflammation
Molecular Metabolism·2025Open Access
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer
UNC Libraries·2025Open Access
Structural basis for mTORC1 regulation by the CASTOR1–GATOR2 complex
Nature Structural & Molecular Biology·2025· 6 citedOpen Access
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer
Nature·2025· 21 cited
Structural basis for mTORC1 regulation by the CASTOR1-GATOR2 complex
2025· 1 citedOpen Access
Cholesterol finds its pocket in LYCHOS
Nature Structural & Molecular Biology·2025
PCSK9 dependent cholesterol acquisition and utilization underlies metastatic organ preference in pancreatic cancer
2025Open Access
Autophagosomes anchor an AKAP11-dependent regulatory checkpoint that shapes neuronal PKA signaling
The EMBO Journal·2025· 6 citedOpen Access
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Science·2025· 6 citedOpen Access
Illuminating cholesterol-mTORC1 signaling: LYCHOS in focus
Structure·2025
Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
2024Open Access
mTORC1 Signaling Inhibition Modulates Mitochondrial Function in Frataxin Deficiency
2024Open Access
Autophagosomes coordinate an AKAP11-dependent regulatory checkpoint that shapes neuronal PKA signaling
2024· 3 citedOpen Access
HSDL2 links nutritional cues to bile acid and cholesterol homeostasis
Science Advances·2024· 14 citedOpen Access
Abstract C103: Differential acquisition of extracellular lipid correlates with pancreatic cancer subtype and metastatic tropism
Cancer Research·2024
Author Correction: The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
Nature Reviews Molecular Cell Biology·2023· 9 citedOpen Access
The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
Nature Reviews Molecular Cell Biology·2023· 200 cited
Emerging roles of the MiT/TFE factors in cancer
Trends in cancer·2023· 25 cited
Chemical Methods from A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles
2023Open Access
Supplemental Figures S1-S7 and Supplemental Table S1 from A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles
2023Open Access
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Frequent Co-authors

David M. Sabatini(14), Rushika M. Perera(13), Daniel K. Nomura(7), Alejo Efeyan(6), Liron Bar‐Peled(6), Rosalie Lawrence(6), Pietro De Camilli(6), Derek Toomre(6), Hijai R. Shin(6), Oliver B. Davis(5), James H. Hurley(5), Chun-Yan Lim(4), James A. Olzmann(3), Yasemin Sancak(3), Rachel L. Wolfson(3), Brian M. Castellano(3), Ashley Thelen(3), Dojin Kim(3), Breanna Ford(2), Carmine Settembre(2)