Hijai R. Shin

Children's Medical Center — United States

Medicine · Health Sciences

14h-index2.0kcitations33works0.32yr avg
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Research Topics

Autophagy in Disease and Therapy(10), Calcium signaling and nucleotide metabolism(7), Epigenetics and DNA Methylation(6), Cellular transport and secretion(6), Cardiac Valve Diseases and Treatments(5)

Publications33 total

Cholesterol finds its pocket in LYCHOS
Nature Structural & Molecular Biology·2025
Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction
Cell chemical biology·2025· 1 cited
Illuminating cholesterol-mTORC1 signaling: LYCHOS in focus
Structure·2025
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1
Science·2022· 118 citedOpen Access
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth
Nature Cell Biology·2021· 71 citedOpen Access
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth
2021· 5 citedOpen Access
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
Developmental Cell·2020· 190 citedOpen Access
Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy
Nature Communications·2020· 55 citedOpen Access
The hypothalamic–pituitary–gonadal axis controls muscle stem cell senescence through autophagosome clearance
Journal of Cachexia Sarcopenia and Muscle·2020· 14 citedOpen Access
NPC1-mTORC1 signaling Couples Cholesterol Sensing to Organelle Homeostasis and is a Targetable Pathway in Niemann-Pick type C
2020· 5 citedOpen Access
The Lysosome at the Intersection of Cellular Growth and Destruction
Developmental Cell·2020· 109 citedOpen Access
Autophagy and multivesicular body formation in blastocysts during the experimental diapause in mice
Bioscientifica Proceedings·2020Open Access
ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C
Nature Cell Biology·2019· 301 cited
Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition
Nature Chemical Biology·2019· 179 cited
Finding Sugar in the Pantry: How Galectins Detect and Signal Lysosomal Damage
Molecular Cell·2018· 6 citedOpen Access
PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response
Molecular Cell·2018· 93 cited
Epigenetic and transcriptional regulation of autophagy
Autophagy·2016· 54 citedOpen Access
AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy
Nature·2016· 435 citedOpen Access
Epigenetic and Transcriptional Regulation of Autophagy
Figshare·2016Open Access
Epigenetic and transcriptional regulation of autophagy
Figshare·2016Open Access
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Frequent Co-authors

Roberto Zoncu(11), Sung Hee Baek(10), Keun Il Kim(6), Rushika M. Perera(5), Hyun-Kyung Kim(4), Oliver B. Davis(4), Kyoung‐Jae Won(3), Daniel K. Nomura(3), Chun-Yan Lim(3), Daehee Hwang(3), Hye Jin Nam(3), Dongha Kim(3), Kiyokazu Kokaji(3), Charles A. Berdan(2), Emma Wu(2), Matthew A. Kukurugya(2), Claire Maher(2), M. Paulina Ordoñez(2), Jason S. Lee(2), Yun-Ho Kim(2)