Xin Gu

Harvard University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index3.9kcitations56works3.42yr avg
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Research Topics

Ubiquitin and proteasome pathways(8), Cellular transport and secretion(7), PI3K/AKT/mTOR signaling in cancer(6), Nitric Oxide and Endothelin Effects(5), Ion channel regulation and function(5)

Publications56 total

FOXS1 promotes cancer cachexia-induced muscle atrophy by down-regulating PIK3IP1 to activate the PI3K/AKT signaling
Molecular & Cellular Toxicology·2025
Ribosome remodeling drives translation adaptation during viral infection and cellular stress
2025Open Access
Midnolin Downregulation Promotes Myelomagenesis via Impacting Ubiquitination Independent Pathway of Protein Degradation
Clinical Lymphoma Myeloma & Leukemia·2025
Structure of the TXNL1-bound proteasome
Nature Structural & Molecular Biology·2025· 3 citedOpen Access
“War” or “Peace”: an study of Chinese mainstream media and weibo discussions in the context of the Israel-Palestine conflict — based on machine learning approach
International Communication of Chinese Culture·2025· 1 cited
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
Molecular Cell·2025· 9 citedOpen Access
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
2025· 2 citedOpen Access
A Transformer Based on Feedback Attention Mechanism for Diagnosis of Coronary Heart Disease Using Echocardiographic Images
Computers, materials & continua/Computers, materials & continua (Print)·2025· 1 citedOpen Access
Determination of Nutrient Ligand-Sensor Binding Affinity
Methods in molecular biology·2025
Structure of the TXNL1-bound proteasome
2024· 3 citedOpen Access
Rag–Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway
Proceedings of the National Academy of Sciences·2024· 18 citedOpen Access
The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
Science·2023· 131 citedOpen Access
The Rag GTPases-mTORC1-TFE3 Axis in Kidney Cancer and Neurodevelopment: A Mini Review
Journal of Neurology and Neuromedicine·2023Open Access
A central role for regulated protein stability in the control of TFE3 and MITF by nutrients
Molecular Cell·2023· 47 citedOpen Access
The regulatory roles of circular RNAs via autophagy in ischemic stroke
Frontiers in Neurology·2022· 7 citedOpen Access
Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila
Nature·2022· 4 citedOpen Access
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila
Nature·2022· 55 citedOpen Access
Structure of the nutrient-sensing hub GATOR2
Nature·2022· 72 citedOpen Access
Sestrin-mediated leucine sensing by mTORC1 is essential for detecting and adapting to a low leucine diet in Drosophila
2020Open Access
Structural basis for the docking of mTORC1 on the lysosomal surface
Science·2019· 208 citedOpen Access
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Frequent Co-authors

H. Eric Xu(16), Karsten Melcher(15), Jiyuan Ke(10), Parker W. de Waal(9), David M. Sabatini(9), X. Edward Zhou(8), Christopher Nardone(7), Stephen J. Elledge(6), Yanyong Kang(5), Nolan Kamitaki(5), Max L. Valenstein(5), Ned Van Eps(4), Yi Jiang(4), Steven P. Gygi(4), Mingyue Tan(4), Pranav V. Lalgudi(4), Winifred G. Nayler(4), David Casley(4), Jingjing Gao(4), Matthew C. J. Yip(4)