Parker W. de Waal

D. E. Shaw Research — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index3.3kcitations37works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(18), Neuropeptides and Animal Physiology(7), Photoreceptor and optogenetics research(7), Metabolism, Diabetes, and Cancer(5), Mass Spectrometry Techniques and Applications(4)

Publications37 total

Structural mechanism of a drug-binding process involving a large conformational change of the protein target
Nature Communications·2023· 100 citedOpen Access
Molecular mechanisms of fentanyl mediated β-arrestin biased signaling
PLoS Computational Biology·2020· 55 citedOpen Access
Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
Nature Communications·2020· 124 citedOpen Access
Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors
Molecular Cell·2020· 95 cited
A complex structure of arrestin-2 bound to a G protein-coupled receptor
Cell Research·2019· 217 citedOpen Access
A complex structure of arrestin-2 bound to a G protein-coupled receptor
2019· 11 citedOpen Access
Development of “Plug and Play” Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM
Structure·2019· 25 citedOpen Access
Molecular mechanisms of fentanyl mediated β-arrestin biased signaling
2019· 3 citedOpen Access
A complex structure of arrestin-2 bound to neurotensin receptor 1
2019
Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 2 receptor in complex with Gs protein and Nb35
2019
Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 1 receptor in complex with Gs protein and Nb35
2019
Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi
2019
Structure and dynamics of the active human parathyroid hormone receptor-1
Science·2019· 260 citedOpen Access
Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK)
Journal of Biological Chemistry·2018· 19 citedOpen Access
Crystal structure of the Frizzled 4 receptor in a ligand-free state
Nature·2018· 116 cited
Publisher Correction: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein
Nature·2018· 4 citedOpen Access
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein
Nature·2018· 273 citedOpen Access
Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist
Cell Discovery·2018· 79 citedOpen Access
Rhodopsin-Gi complex
2018
Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors
Cell·2017· 439 citedOpen Access
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Frequent Co-authors

Karsten Melcher(34), H. Eric Xu(30), X. Edward Zhou(16), Yi Jiang(13), Yanyong Kang(10), Yanting Yin(10), Xin Gu(9), Xiang Gao(8), Jiyuan Ke(8), Yuanzheng He(7), Ned Van Eps(6), Kuntal Pal(6), Oliver P. Ernst(5), Patrick R. Griffin(5), Raymond C. Stevens(5), Xing Meng(5), Gongpu Zhao(5), Lihua Zhao(5), Xiaoxi Wang(5), Bradley M. Dickson(5)