Len Stephens

Babraham Institute — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

76h-index24.4kcitations226works1.82yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(88), PI3K/AKT/mTOR signaling in cancer(53), Cellular transport and secretion(46), Neutrophil, Myeloperoxidase and Oxidative Mechanisms(34), Pancreatic function and diabetes(18)

Publications225 total

Editorial: Celebrating 50 years of insight—Bob Michell's legacy in phosphoinositide signalling
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2025
FGF-induced phospholipase Cγ signaling regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism
Cell Reports·2025· 1 citedOpen Access
The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types
Nature Genetics·2025· 8 citedOpen Access
Phosphoinositide acyl chain diversity: comparative analysis across species and mouse tissues
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2025Open Access
Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling
PLoS Biology·2025· 1 citedOpen Access
CDS2 expression regulates <i>de novo</i> phosphatidic acid synthesis
Biochemical Journal·2024· 4 citedOpen Access
The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signaling
Molecular Biology of the Cell·2024· 2 citedOpen Access
Phospholipase Cγ regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism
2024Open Access
p110α-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD
2024Open Access
P‐TS‐53 | Liver Transplantation in a Highly Alloimmunized Patient with Sickle Cell Disease and Complex Blood Product Requirements
Transfusion·2023Open Access
P‐IS‐2 | Catching a Cold: Assessment of Cold Antibody Detection on Column Agglutination Technology
Transfusion·2023
P‐MG‐2 | Environmental Impact of a Transfusion Medicine Laboratory's Printing
Transfusion·2023Open Access
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
Molecular Cell·2023· 12 citedOpen Access
Genome-wide CRISPR-Cas9 screening to identify <i>CDS2 </i>as an essential gene in uveal melanoma.
Journal of Clinical Oncology·2023· 1 cited
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Nature·2023· 138 citedOpen Access
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
2023Open Access
Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models
Journal of Clinical Investigation·2023· 14 citedOpen Access
The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signalling
2023· 1 citedOpen Access
Tickling APCsThe p84/p110 complex of PI3K regulates NOX2 assembly and cross-presentation of immune complexes
Molecular Immunology·2022
<scp>ARFs</scp> get the <scp>BioID</scp> treatment: what have we been missing?
The EMBO Journal·2022· 1 citedOpen Access
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Frequent Co-authors

Phillip T. Hawkins(45), Karen E. Anderson(15), Trevor Jackson(9), Chris D. Ellson(9), Keith Davidson(8), Roger Williams(7), John Coadwell(7), Gail Ferguson(7), Olga Perišić(6), A. Eguinoa(6), Hediye Erdjument‐Bromage(5), Paul Tempst(5), Frank T. Cooke(5), Heidi C. E. Welch(5), Simon Andrews(5), Andrew B. Holmes(4), Jonathan Clark(4), Edwin R. Chilvers(4), Klaus Okkenhaug(4), W. John Coadwell(4)