Roger Williams

MRC Laboratory of Molecular Biology — United Kingdom

Medicine · Health Sciences

125h-index67.2kcitations1.2kworks2.52yr avg
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Research Topics

Liver Disease Diagnosis and Treatment(233), Liver Disease and Transplantation(130), Hepatitis B Virus Studies(113), Liver Diseases and Immunity(110), Hepatitis C virus research(90)

Publications1.2k total

Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop
2026Open Access
A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution
2025Open Access
Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome
Disease Models & Mechanisms·2025· 1 citedOpen Access
TTP5.14 Use of Percutaneous Cholecystostomy in Elderly and Patients with Multiple Co-morbidities
British journal of surgery·2025
A mouse model of PTEN Hamartoma Tumour Syndrome reveals that loss of the nuclear function of PTEN drives macrocephaly, lymphoid overgrowth, and late-onset cancer
2025Open Access
Preventing and Managing Tracheostomy-Related Emergencies in the Radiology Suite: Best Practices for Safety and Preparedness
Journal of Radiology Nursing·2025· 2 cited
Author response: Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
2025Open Access
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
eLife·2025Open Access
The link of <scp>FOXO1</scp> and <scp>FOXO4</scp> transcription factors to development of the lens
Developmental Dynamics·2025· 4 citedOpen Access
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
2025Open Access
Author response: Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
2025Open Access
Making PI3K superfamily enzymes run faster
Advances in Biological Regulation·2024· 2 citedOpen Access
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding
Biochemical Journal·2024· 3 citedOpen Access
Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function
Science·2024· 35 citedOpen Access
Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis
Oncogene·2024· 3 citedOpen Access
Epidural Steroid Injection Technique
Techniques in vascular and interventional radiology·2024
The US regulatory and pharmacopeia response to the global heparin contamination crisis
UNC Libraries·2024Open Access
Reviewer #2 (Public Review): Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
2024Open Access
Reviewer #1 (Public Review): Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
2024Open Access
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
2024Open Access
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Frequent Co-authors

Olga Perišić(14), Len Stephens(5), Phillip T. Hawkins(4), Kevan M. Shokat(4), Edward H. Walker(3), Michael E. Pacold(3), Beatriz González(3), Stephanie Reignat(3), Graham S. Ogg(3), Diego Vergani(3), Antonio Bertoletti(3), Nancy Rolando(3), John Philpott‐Howard(3), Oscar Vadas(3), John E. Burke(3), Glenn R. Masson(3), Zachary A. Knight(2), Morri E. Feldman(2), Olusegun Williams(2), Mala K. Maini(2)