Lisa Strasser

National Institute for Bioprocessing Research and Training — Ireland

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index274citations31works4.02yr avg
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Research Topics

Virus-based gene therapy research(12), Viral Infectious Diseases and Gene Expression in Insects(12), Protein purification and stability(8), Monoclonal and Polyclonal Antibodies Research(6), Immunotherapy and Immune Responses(5)

Publications31 total

Detection of host cell microprotein impurities in antibody drug products
Nature Communications·2024· 6 citedOpen Access
A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency
International Journal of Molecular Sciences·2024· 2 citedOpen Access
Development of a Rapid Adeno-Associated Virus (AAV) Identity Testing Platform through Comprehensive Intact Mass Analysis of Full-Length AAV Capsid Proteins
Journal of Proteome Research·2023· 13 citedOpen Access
CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms
Advanced Science·2023· 12 citedOpen Access
Exploring Charge-Detection Mass Spectrometry on Chromatographic Time Scales
Analytical Chemistry·2023· 20 citedOpen Access
Mass spectrometry friendly pH-gradient anion exchange chromatography for separation of full and empty Adeno-Associated Virus (AAV) capsids
2023· 1 citedOpen Access
Development of a Rapid Adeno-Associated Virus (AAV) Identity Testing Platform through Comprehensive Mass Analysis of Full-length AAV Capsid Proteins
2023· 1 citedOpen Access
SP3-based host cell protein monitoring in AAV-based gene therapy products using LC-MS/MS
European Journal of Pharmaceutics and Biopharmaceutics·2023· 10 citedOpen Access
Mass spectrometry friendly pH-gradient anion exchange chromatography for the separation of full and empty adeno-associated virus (AAV) capsids
Analytical Methods·2023· 9 citedOpen Access
Annotation of the non-canonical translatome reveals that CHO cell microproteins are a new class of mAb drug product impurity
2022Open Access
Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells
International Journal of Molecular Sciences·2021· 34 citedOpen Access
Fast and efficient digestion of adeno associated virus (AAV) capsid proteins for liquid chromatography mass spectrometry (LC-MS) based peptide mapping and post translational modification analysis (PTMs)
Journal of Pharmaceutical and Biomedical Analysis·2021· 31 citedOpen Access
A Native Mass Spectrometry-Based Assay for Rapid Assessment of the Empty:Full Capsid Ratio in Adeno-Associated Virus Gene Therapy Products
Analytical Chemistry·2021· 19 citedOpen Access
Fast and efficient digestion of adeno associated virus (AAV) capsid proteins for liquid chromatography mass spectrometry (LC-MS) based peptide mapping and post translational modification analysis (PTMs)
2021· 2 citedOpen Access
Optimization Strategies in <scp>HPLC</scp> for the Separation of Biomolecules
2021
A native mass spectrometry-based assay for rapid assessment of the empty/full capsid ratio in AAV gene therapy products
2021Open Access
Native LC–MS for capturing quality attributes of biopharmaceuticals on the intact protein level
Current Opinion in Biotechnology·2021· 40 citedOpen Access
Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS
Journal of Pharmaceutical Analysis·2021· 23 citedOpen Access
Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality
Frontiers in Bioengineering and Biotechnology·2021· 13 citedOpen Access
In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization
Frontiers in Immunology·2020· 14 citedOpen Access
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Frequent Co-authors

Jonathan Bones(19), Felipe Guapo(12), Christian G. Huber(12), Florian Füssl(9), Jutta Horejs‐Hoeck(9), Ian Anderson(5), Niall Barron(4), Silvia Millán‐Martín(4), Sara Carillo(3), Tomos E. Morgan(3), Barry L. Karger(3), Josh Smith(3), Steven G. Milian(3), Richard O. Snyder(3), Colin Clarke(3), Fátima Ferreira(3), Tamara Scheidt(3), Christina Maria Ramsauer(3), Stefano Boi(2), Nicholas Donohue(2)