George J. Leslie

Immunology and Microbiology · Life Sciences

20h-index3.0kcitations35works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

HIV Research and Treatment(26), Immune Cell Function and Interaction(19), Immunotherapy and Immune Responses(10), HIV/AIDS drug development and treatment(8), T-cell and B-cell Immunology(3)

Publications35 total

A survey of the thinking preferences and hemispheric learning strategies (methods) of freshmen and senior associate degree nursing students and the thinking preferences of associate degree nursing faculty.
Scholarworks (University of Massachusetts Amherst)·2023Open Access
HIV-1–Infected CD4+ T Cells Present MHC Class II–Restricted Epitope via Endogenous Processing
The Journal of Immunology·2022· 7 citedOpen Access
A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection
PLoS Pathogens·2022· 6 citedOpen Access
V3 Loop Truncations in HIV-1 Envelope Impart Resistance to Coreceptor Inhibitors and Enhanced Sensitivity to Neutralizing Antibodies
UNC Libraries·2020Open Access
Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo
Nature Medicine·2020· 121 citedOpen Access
Tetherin downmodulation by SIVmac Nef lost with the H196Q escape variant is restored by an upstream variant
PLoS ONE·2020· 4 citedOpen Access
Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus
PLoS Pathogens·2016· 48 citedOpen Access
427. In Vivo Inhibition of HIV-1 in NSG Mice After Transduction of Primary Human T Cells with CXCR4 Conjugated to an HR2 Peptide
Molecular Therapy·2016Open Access
Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus
Journal of Virology·2016· 10 citedOpen Access
Policies and Incentives Offered by the Top Ten American States in Biotechnology that Promote Start-Up Activities
Technology Transfer and Entrepreneurship·2014
Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions
Retrovirology·2013· 42 citedOpen Access
Structure-Based Identification and Neutralization Mechanism of Tyrosine Sulfate Mimetics That Inhibit HIV-1 Entry
ACS Chemical Biology·2011· 32 cited
Distinct Molecular Pathways to X4 Tropism for a V3-Truncated Human Immunodeficiency Virus Type 1 Lead to Differential Coreceptor Interactions and Sensitivity to a CXCR4 Antagonist
Journal of Virology·2010· 9 citedOpen Access
HIV-1 entry and the CCR5 amino terminus
Scholarly Commons (University of Pennsylvania)·2010
Derivation and Characterization of a Simian Immunodeficiency Virus SIVmac239 Variant with Tropism for CXCR4
Journal of Virology·2009· 22 citedOpen Access
Characterization of a Human Immunodeficiency Virus Type 1 V3 Deletion Mutation That Confers Resistance to CCR5 Inhibitors and the Ability To Use Aplaviroc-Bound Receptor
Journal of Virology·2009· 28 citedOpen Access
V3 Loop Truncations in HIV-1 Envelope Impart Resistance to Coreceptor Inhibitors and Enhanced Sensitivity to Neutralizing Antibodies
PLoS Pathogens·2007· 75 citedOpen Access
Replication-Competent Variants of Human Immunodeficiency Virus Type 2 Lacking the V3 Loop Exhibit Resistance to Chemokine Receptor Antagonists
Journal of Virology·2007· 30 citedOpen Access
A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo
Virology·2006· 3 cited
Amino Acid 324 in the Simian Immunodeficiency Virus SIVmac V3 Loop Can Confer CD4 Independence and Modulate the Interaction with CCR5 and Alternative Coreceptors
Journal of Virology·2004· 32 citedOpen Access
page 1 of 2Next →

Frequent Co-authors

Robert W. Doms(17), James A. Hoxie(17), Stefan Pöhlmann(11), Beth Haggarty(11), Josephine Romano(9), Frédéric Baribaud(8), Andrea P. O. Jordan(8), Benhur Lee(6), Frank Kirchhoff(6), James L. Riley(4), Katrina M. Nolan(4), Gregory Q. Del Prete(4), Elizabeth J. Soilleux(3), Nicholas Coleman(3), George Lin(3), Jan Münch(3), Jacqueline D. Reeves(3), Michael C. Holmes(3), Silke Meister(3), Mandy Krumbiegel(3)