Kay Brickmann

AstraZeneca (Sweden) — Sweden

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index383citations22works0.02yr avg
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Research Topics

Chemical Synthesis and Analysis(7), Asymmetric Synthesis and Catalysis(4), Catalytic Alkyne Reactions(3), Neuroendocrine regulation and behavior(3), Chemical Reaction Mechanisms(3)

Publications22 total

5-Alkyl-1,3-Oxazole Derivatives of 6-Amino-Nicotinic Acids as Alkyl Ester Bioisosteres are Antagonists of the P2Y <sub>12</sub> Receptor
Future Medicinal Chemistry·2013· 14 cited
Synthesis, structure–property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor
European Journal of Medicinal Chemistry·2013· 42 citedOpen Access
A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor
Bioorganic & Medicinal Chemistry Letters·2011· 32 citedOpen Access
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats
Bioorganic & Medicinal Chemistry·2011· 27 citedOpen Access
Design, synthesis and biological evaluation of thrombin inhibitors based on a pyridine scaffold
Organic & Biomolecular Chemistry·2007· 6 cited
Synthesis of a β-strand mimetic based on a pyridine scaffold
Tetrahedron·2006· 21 cited
Synthesis and biological evaluation of leucine enkephalin turn mimetics
Organic & Biomolecular Chemistry·2006· 14 cited
Synthesis and Conformational Studies of a β-Turn Mimetic Incorporated in Leu-enkephalin
The Journal of Organic Chemistry·2004· 27 cited
Conformations and Receptor Activity of Desmopressin Analogues, Which Contain γ-Turn Mimetics or a Ψ[CH<sub>2</sub>O] Isostere
Journal of Medicinal Chemistry·2002· 17 cited
Synthesis and Pharmacological Evaluation of an Analogue of the Peptide Hormone Oxytocin That Contains a Mimetic of an Inverse γ-Turn
Journal of Medicinal Chemistry·2002· 26 cited
Synthesis of Conformationally Restricted Mimetics of -Turns and Incorporation into Desmopressin, an Analogue of the Peptide Hormone Vasopressin
Chemistry - A European Journal·1999
Synthesis of Conformationally Restricted Mimetics of γ-Turns and Incorporation into Desmopressin, an Analogue of the Peptide Hormone Vasopressin
Chemistry - A European Journal·1999· 37 cited
ChemInform Abstract: An Approach to Enantiomerically Pure Inverse γ‐Turn Mimetics for Use in Solid‐Phase Synthesis.
ChemInform·1997· 1 cited
An approach to enantiomerically pure inverse γ-turn mimetics for use in solid-phase synthesis
Tetrahedron Letters·1997· 18 cited
ChemInform Abstract: Synthesis of 6‐/10‐Membered Ring Analogues of the Dienediyne Core of the Neocarzinostatin Chromophore by Palladium(0)‐Mediated Ring‐Closure Reactions.
ChemInform·1996
Synthesis of 6‐/10‐Membered Ring Analogs of the Dienediyne Core of the Neocarzinostatin Chromophore by Palladium(0)‐Mediated Ring‐Closure Reactions
Liebigs Annalen·1996· 17 cited
ChemInform Abstract: (2,3)‐Thia‐Wittig Rearrangements of α‐Lithiated Sulfides via De‐ Aromatized Cyclohexadiene Intermediates Proceed with Inversion of Configuration at the Carbanionic Center.
ChemInform·1995
[2,3]‐Thia‐Wittig Rearrangements of α‐Lithiated Sulfides Via De‐aromatized Cyclohexadiene Intermediates Proceed with Inversion of Configuration at the Carbanionic Center
Chemische Berichte·1994· 18 cited
ChemInform Abstract: Study of the Regioselectivity of Palladium‐Catalyzed Monocouplings Between Conjugated Bis(enoltriflates) and Trimethylsilylacetylene.
ChemInform·1994
Study of the regioselectivity of palladium-catalyzed monocouplings between conjugated bis(enoltriflates) and trimethylsilylacetylene
Tetrahedron Letters·1994· 22 cited
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Frequent Co-authors

Jan Kihlberg(10), Ingmar Sethson(5), David J. Blomberg(5), Reinhard Brückner(4), Peter Somfai(4), Jean Suffert(4), Frank Hambloch(4), R. BRUECKNER(4), Peter Bach(3), Jonas Boström(3), Fredrik R. Zetterberg(3), Zhong-Qing Yuan(3), J.J.J. van Giezen(2), Robert D. Groneberg(2), Darren M. Harvey(2), Michael O’Sullivan(2), Ragnar Hovland(2), Mattias Hedenström(2), Paul Kreye(2), Kjell Ekholm(2)