Giuseppe Orsomando

Marche Polytechnic University — Italy

Medicine · Health Sciences

32h-index3.2kcitations79works2.42yr avg
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Research Topics

Sirtuins and Resveratrol in Medicine(30), Calcium signaling and nucleotide metabolism(24), PARP inhibition in cancer therapy(15), Autophagy in Disease and Therapy(12), Biochemical and Molecular Research(11)

Publications79 total

Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy
Journal of Medicinal Chemistry·2026Open Access
Cancer cell death induced by the <scp>NAD</scp> antimetabolite Vacor discloses the antitumor potential of <scp>SARM1</scp>
FEBS Letters·2025Open Access
SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides
Neurobiology of Disease·2025· 4 citedOpen Access
Chronically Low NMNAT2 Expression Causes Sub-lethal SARM1 Activation and Altered Response to Nicotinamide Riboside in Axons
Molecular Neurobiology·2024· 5 citedOpen Access
SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides
2024· 5 citedOpen Access
Chronically low NMNAT2 expression causes sub-lethal SARM1 activation and altered response to nicotinamide riboside in axons
2024· 2 citedOpen Access
Adaptation of a Commercial NAD+ Quantification Kit to Assay the Base-Exchange Activity and Substrate Preferences of SARM1
Molecules·2024· 1 citedOpen Access
Adaptation of a commercial NAD quantification kit to assay the base exchange activity of SARM1
2023Open Access
The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila
eLife·2022· 31 citedOpen Access
Author response: The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila
2022Open Access
The NAD <sup>+</sup> precursor NMN activates dSarm to trigger axon degeneration in <i>Drosophila</i>
2022Open Access
SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites
iScience·2022· 85 citedOpen Access
Author response: Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1
2021Open Access
Neurotoxin-mediated --potent activation of the axon degeneration regulator SARM1.
Apollo (University of Cambridge)·2021· 21 citedOpen Access
Programmed axon death executor SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated by physiological levels of NMN, NAD, NADP and other metabolites
2021· 10 citedOpen Access
Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity
2020· 15 citedOpen Access
Functional Characterization of COG1713 (YqeK) as a Novel Diadenosine Tetraphosphate Hydrolase Family
Journal of Bacteriology·2020· 20 citedOpen Access
A nicotinamide phosphoribosyltransferase–GAPDH interaction sustains the stress-induced NMN/NAD+ salvage pathway in the nucleus
Journal of Biological Chemistry·2020· 34 citedOpen Access
Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration
Neurobiology of Disease·2019· 131 citedOpen Access
Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration
2019· 10 citedOpen Access
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Frequent Co-authors

Nadia Raffaelli(17), Silverio Ruggieri(17), Adolfo Amici(16), Giulio Magni(15), Michael P. Coleman(14), Jonathan Gilley(12), Carlo Alberto Angeletti(10), Andrea Loreto(9), Leonardo Sorci(9), Francesca Mazzola(8), Laura Conforti(7), M. Di Stefano(6), Riccardo Petrelli(5), Monica Emanuelli(4), Luca A. Vitali(4), Loredana Cappellacci(4), Giulio Lupidi(4), Filippo Maggi(4), Dezemona Petrelli(4), Luana Quassinti(4)