John Blenis

Cornell University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

112h-index67.1kcitations326works13.82yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(94), Protein Kinase Regulation and GTPase Signaling(71), Melanoma and MAPK Pathways(41), Cancer, Hypoxia, and Metabolism(32), RNA modifications and cancer(24)

Publications326 total

Mineralocorticoid and glucocorticoid receptor interaction drives TGFβ1-induced triple-negative breast cancer progression to metastasis
2025Open Access
TMET-28. Omega-6 arachidonic acid induces oxidative stress and suppresses tumor growth as part of a ketogenic diet in mice with glioblastoma
Neuro-Oncology·2025Open Access
Propionate metabolism dysregulation promotes drug-tolerant persister cell survival in non-small cell lung cancer
2025Open Access
Lysosome-dependent nutrient scavenging underlies stress adaptation during epithelial-to-mesenchymal transition
2025Open Access
Abstract 3831: A molecular landscape of epithelial to mesenchymal transition reveals dependencies on lysosomes and nutrient scavenging
Cancer Research·2025
Abstract 3802: Isoleucine and valine promote prostate cancer progression via propionyl-CoA-mediated cholesterol metabolism
Cancer Research·2025
Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
Science·2025· 25 cited
The emerging role of dysregulated propionate metabolism and methylmalonic acid in metabolic disease, aging, and cancer
Cell Metabolism·2025· 12 citedOpen Access
Retraction Notice to: The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B- Dependent Control of c-Myc Translation
Current Biology·2024
mTORC1, the maestro of cell metabolism and growth
Genes & Development·2024· 30 citedOpen Access
Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing
Molecular Cell·2024· 14 citedOpen Access
The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization
2024Open Access
Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase
Proceedings of the National Academy of Sciences·2024· 4 citedOpen Access
The intrinsic substrate specificity of the human tyrosine kinome
Nature·2024· 118 citedOpen Access
Decoding Serine Metabolism: Unveiling Novel Pathways for Evolving Cancer Therapies
Cancer Research·2024· 4 cited
Nutrient signaling: Starvation flips a phosphoinositide switch on lysosomal catabolism
Current Biology·2023Open Access
Ran-Binding Protein 3 Phosphorylation Links the Ras and PI3-Kinase Pathways to Nucleocytoplasmic Transport
Molecular Cell·2023· 1 cited
LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase
2023Open Access
Balancing lysosome abundance in health and disease
Nature Cell Biology·2023· 51 cited
FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1
Molecular Cell·2023· 26 citedOpen Access
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Frequent Co-authors

Lewis C. Cantley(9), Philippe P. Roux(6), Diane C. Fingar(6), Andrew R. Tee(4), Leon O. Murphy(4), Peter Juo(3), Brendan D. Manning(3), Marina K. Holz(3), Bryan A. Ballif(3), Steven P. Gygi(3), Jongkyeong Chung(3), Xiaoju Max(2), Sang Gyun Kim(2), Calvin J. Kuo(2), Rey‐Huei Chen(2), Charlyn Sarnecki(2), Christina Tsou(2), Bentley Cheatham(2), Chris J. Vlahos(2), Lynn Cheatham(2)