Philippe P. Roux

Institute for Research in Immunology and Cancer — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

56h-index20.5kcitations204works2.52yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(39), Protein Kinase Regulation and GTPase Signaling(35), Melanoma and MAPK Pathways(28), Ubiquitin and proteasome pathways(21), 14-3-3 protein interactions(18)

Publications204 total

The deubiquitinase USP17 regulates the expression and activity of the oncogenic driver β-catenin in colorectal cancer
Oncogene·2026
A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture
2026Open Access
Control of cellular cortical tension and shape by RhoGTPase signalling
2025Open Access
Supplementary Figures from HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer
2025Open Access
Supplementary Data Legends from HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer
2025Open Access
CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability
Cell Reports·2025Open Access
CDK11 activates CDK12 to trigger the elongation of RNA Polymerase II
2025Open Access
Increased activity of PRMT5-MEP50 complex improves survival of chromosomally unstable cancer cells by increasing tolerance to protein aggregation and proteotoxicity
2025Open Access
mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport
Molecular Cell·2025· 1 citedOpen Access
A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of concept
2025Open Access
14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation
Molecular Metabolism·2025· 3 citedOpen Access
IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia
Biomarker Research·2025· 4 citedOpen Access
Immunosuppressive myeloid cells induce mesenchymal-like breast cancer stem cells by a mechanism involving membrane-bound TGF-β1
2025Open Access
Supplementary Data Legends from HER2∆16 Engages ENPP1 To Promote an Immune Cold Microenvironment in Breast Cancer
2024Open Access
Supplementary Figures from HER2∆16 Engages ENPP1 To Promote an Immune Cold Microenvironment in Breast Cancer
2024Open Access
Data from HER2∆16 Engages ENPP1 To Promote an Immune Cold Microenvironment in Breast Cancer
2024Open Access
Supplementary Data Legends from HER2∆16 Engages ENPP1 To Promote an Immune Cold Microenvironment in Breast Cancer
2024Open Access
Supplementary Figures from HER2∆16 Engages ENPP1 To Promote an Immune Cold Microenvironment in Breast Cancer
2024Open Access
The expanding landscape of canonical and non-canonical protein phosphorylation
Trends in Biochemical Sciences·2024· 18 cited
Immunotherapeutic targeting of surfaceome heterogeneity in AML
Cell Reports·2024· 23 citedOpen Access
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Frequent Co-authors

John Blenis(11), Bryan A. Ballif(6), Yves Roméo(6), Pierre Thibault(6), Joseph Tcherkezian(6), Marie Cargnello(5), Audrey Carrière(5), Geneviève Lavoie(5), Steven P. Gygi(4), Guillaume Charras(4), Ewa K. Paluch(4), Ivan Topisirović(3), Léo Aubert(3), Sébastien Lemieux(3), Timothy E. Kennedy(3), Sang-Oh Yoon(2), David Shahbazian(2), Michael S. Cohen(2), Jack Taunton(2), Nahum Sonenberg(2)